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- Publisher Website: 10.1902/jop.2005.76.3.341
- Scopus: eid_2-s2.0-18744402174
- PMID: 15857066
- WOS: WOS:000228660100004
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Article: Clinical performance of a regenerative strategy for intrabony defects: Scientific evidence and clinical experience
Title | Clinical performance of a regenerative strategy for intrabony defects: Scientific evidence and clinical experience |
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Authors | |
Keywords | Bone regeneration Comparison studies Enamel matrix derivative Grafts, bone Membranes, artificial Membranes, bioabsorbable Periodontal regeneration Titanium |
Issue Date | 2005 |
Citation | Journal of Periodontology, 2005, v. 76, n. 3, p. 341-350 How to Cite? |
Abstract | Background: The aim of the present study was to evaluate the clinical performance of a regenerative strategy for the treatment of deep intrabony defects. Methods: This patient cohort study involved 40 patients with one deep interdental intrabony defect each. They were treated with periodontal regeneration using four different regenerative methods (expanded polytetrafluoroethylene [ePTFE] titanium reinforced membranes, bioabsorbable membranes alone, bioabsorbable membranes with a bone replacement graft [combination], or enamel matrix derivative), according to predefined criteria and decision-making algorithms. Defects were accessed with papilla preservation flaps performed with the aid of an operating microscope and microsurgical instruments. A stringent plaque control regimen was enforced in all the patients during the 1-year observation period. Outcomes included evaluation of the complete primary closure of the interdental space (CLOSURE), gains in clinical attachment (CAL), and reductions in probing depths (PD). Results: CLOSURE was achieved in all treated defects and was maintained in 90% of cases for the entire healing period. At 1 year the observed CAL gains were 6 ± 1.8 mm on average, corresponding to a resolution of 92.1% ± 12% of the initial intrabony (CAL%) component of the defect. Average PD reduction was 6.1 ± 1.9 mm and was associated with minimal increase in gingival recession (-0.1 ± 0.7 mm). The 12 sites treated with titanium reinforced ePTFE membranes resulted in a 1-year CAL gain of 6.8 ± 2.2 mm (CAL%: 94.7 ± 13.4); the 11 cases treated with combination therapy showed a 1-year CAL gain of 5.4 ± 1.7 mm (CAL%: 88.2 ± 9.6); the seven sites treated with bioabsorbable barriers resulted in 5.9 ± 1.2 mm of CAL gain (CAL%: 88.9 ± 11.5); and the 10 sites treated with enamel matrix gained on average 5.9 ± 1.5 mm of CAL (CAL%: 88.9 ± 11.5). No significant differences were observed among the four approaches. Conclusion: The use of an evidence-based regenerative strategy resulted in clinically relevant amounts of CAL gains, shallow pockets, and minimal gingival recession with the four regenerative approaches. |
Persistent Identifier | http://hdl.handle.net/10722/230738 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.362 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cortellini, Pierpaolo | - |
dc.contributor.author | Tonetti, Maurizio S. | - |
dc.date.accessioned | 2016-09-01T06:06:41Z | - |
dc.date.available | 2016-09-01T06:06:41Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Periodontology, 2005, v. 76, n. 3, p. 341-350 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230738 | - |
dc.description.abstract | Background: The aim of the present study was to evaluate the clinical performance of a regenerative strategy for the treatment of deep intrabony defects. Methods: This patient cohort study involved 40 patients with one deep interdental intrabony defect each. They were treated with periodontal regeneration using four different regenerative methods (expanded polytetrafluoroethylene [ePTFE] titanium reinforced membranes, bioabsorbable membranes alone, bioabsorbable membranes with a bone replacement graft [combination], or enamel matrix derivative), according to predefined criteria and decision-making algorithms. Defects were accessed with papilla preservation flaps performed with the aid of an operating microscope and microsurgical instruments. A stringent plaque control regimen was enforced in all the patients during the 1-year observation period. Outcomes included evaluation of the complete primary closure of the interdental space (CLOSURE), gains in clinical attachment (CAL), and reductions in probing depths (PD). Results: CLOSURE was achieved in all treated defects and was maintained in 90% of cases for the entire healing period. At 1 year the observed CAL gains were 6 ± 1.8 mm on average, corresponding to a resolution of 92.1% ± 12% of the initial intrabony (CAL%) component of the defect. Average PD reduction was 6.1 ± 1.9 mm and was associated with minimal increase in gingival recession (-0.1 ± 0.7 mm). The 12 sites treated with titanium reinforced ePTFE membranes resulted in a 1-year CAL gain of 6.8 ± 2.2 mm (CAL%: 94.7 ± 13.4); the 11 cases treated with combination therapy showed a 1-year CAL gain of 5.4 ± 1.7 mm (CAL%: 88.2 ± 9.6); the seven sites treated with bioabsorbable barriers resulted in 5.9 ± 1.2 mm of CAL gain (CAL%: 88.9 ± 11.5); and the 10 sites treated with enamel matrix gained on average 5.9 ± 1.5 mm of CAL (CAL%: 88.9 ± 11.5). No significant differences were observed among the four approaches. Conclusion: The use of an evidence-based regenerative strategy resulted in clinically relevant amounts of CAL gains, shallow pockets, and minimal gingival recession with the four regenerative approaches. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Periodontology | - |
dc.subject | Bone regeneration | - |
dc.subject | Comparison studies | - |
dc.subject | Enamel matrix derivative | - |
dc.subject | Grafts, bone | - |
dc.subject | Membranes, artificial | - |
dc.subject | Membranes, bioabsorbable | - |
dc.subject | Periodontal regeneration | - |
dc.subject | Titanium | - |
dc.title | Clinical performance of a regenerative strategy for intrabony defects: Scientific evidence and clinical experience | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1902/jop.2005.76.3.341 | - |
dc.identifier.pmid | 15857066 | - |
dc.identifier.scopus | eid_2-s2.0-18744402174 | - |
dc.identifier.volume | 76 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 341 | - |
dc.identifier.epage | 350 | - |
dc.identifier.isi | WOS:000228660100004 | - |
dc.identifier.issnl | 0022-3492 | - |