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Article: Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol

TitleShort-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol
Authors
KeywordsAtherosclerosis
Periodontitis
Inflammation
Cholesterol
C-reactive protein
Issue Date2005
Citation
Journal of Dental Research, 2005, v. 84, n. 3, p. 269-273 How to Cite?
AbstractSevere periodontitis has been associated with increased systemic inflammation. In a three-arm preliminary randomized trial, we investigated the impact of standard (SPT) and intensive periodontal therapy (IPT) on serum inflammatory markers and cholesterol levels. Medical and periodontal parameters, C-reactive protein (CRP), interleukin-6 (IL-6), total cholesterol, and LDL cholesterol were evaluated in 65 systemically healthy subjects suffering from severe generalized periodontitis. Two months after treatment, both SPT and IPT resulted in significant reductions in serum CRP compared with the untreated control (0.5 ± 0.2 mg/L for SPT, P = 0.030 and 0.8 ± 0.2 mg/L for IPT, P = 0.001). Similar results were observed for IL-6. Changes in inflammation were independent of age, gender, body mass index, and ethnicity, but a significant interaction between cigarette smoking and treatment regimen was found. The IPT group also showed a decrease in total and LDL cholesterol after 2 months. Analysis of these data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects.
Persistent Identifierhttp://hdl.handle.net/10722/230733
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorD'Aiuto, F.-
dc.contributor.authorNibali, L.-
dc.contributor.authorParkar, M.-
dc.contributor.authorSuvan, J.-
dc.contributor.authorTonetti, M. S.-
dc.date.accessioned2016-09-01T06:06:40Z-
dc.date.available2016-09-01T06:06:40Z-
dc.date.issued2005-
dc.identifier.citationJournal of Dental Research, 2005, v. 84, n. 3, p. 269-273-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/230733-
dc.description.abstractSevere periodontitis has been associated with increased systemic inflammation. In a three-arm preliminary randomized trial, we investigated the impact of standard (SPT) and intensive periodontal therapy (IPT) on serum inflammatory markers and cholesterol levels. Medical and periodontal parameters, C-reactive protein (CRP), interleukin-6 (IL-6), total cholesterol, and LDL cholesterol were evaluated in 65 systemically healthy subjects suffering from severe generalized periodontitis. Two months after treatment, both SPT and IPT resulted in significant reductions in serum CRP compared with the untreated control (0.5 ± 0.2 mg/L for SPT, P = 0.030 and 0.8 ± 0.2 mg/L for IPT, P = 0.001). Similar results were observed for IL-6. Changes in inflammation were independent of age, gender, body mass index, and ethnicity, but a significant interaction between cigarette smoking and treatment regimen was found. The IPT group also showed a decrease in total and LDL cholesterol after 2 months. Analysis of these data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects.-
dc.languageeng-
dc.relation.ispartofJournal of Dental Research-
dc.subjectAtherosclerosis-
dc.subjectPeriodontitis-
dc.subjectInflammation-
dc.subjectCholesterol-
dc.subjectC-reactive protein-
dc.titleShort-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1177/154405910508400312-
dc.identifier.pmid15723869-
dc.identifier.scopuseid_2-s2.0-16844376535-
dc.identifier.volume84-
dc.identifier.issue3-
dc.identifier.spage269-
dc.identifier.epage273-

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