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- Scopus: eid_2-s2.0-0025857502
- PMID: 1846905
- WOS: WOS:A1991ET88900009
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Article: Intracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria
Title | Intracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria |
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Authors | |
Keywords | metabolism oxygen radicals butyrates calorimetry hydrogen ion concentration phagocytes |
Issue Date | 1991 |
Citation | Journal of Leukocyte Biology, 1991, v. 49, n. 2, p. 180-188 How to Cite? |
Abstract | The effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso-butyric, on neutrophil metabolic activation were assessed. SCCA-induced a significant decrease in O 2· - recovery and chemiluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl-phorbol-acetate (TPA). SCCA did not alter O 2 consumption, H 2O 2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pH(i)). These results are consistent with an increased divalent versus univalent O 2 reduction performed by the NADPH oxidase at a more acidic intracellular pH. |
Persistent Identifier | http://hdl.handle.net/10722/230647 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.521 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tonetti, M. | - |
dc.contributor.author | Cavallero, A. | - |
dc.contributor.author | Botta, G. A. | - |
dc.contributor.author | Niederman, R. | - |
dc.contributor.author | Eftimiadi, C. | - |
dc.date.accessioned | 2016-09-01T06:06:27Z | - |
dc.date.available | 2016-09-01T06:06:27Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Journal of Leukocyte Biology, 1991, v. 49, n. 2, p. 180-188 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230647 | - |
dc.description.abstract | The effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso-butyric, on neutrophil metabolic activation were assessed. SCCA-induced a significant decrease in O 2· - recovery and chemiluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl-phorbol-acetate (TPA). SCCA did not alter O 2 consumption, H 2O 2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pH(i)). These results are consistent with an increased divalent versus univalent O 2 reduction performed by the NADPH oxidase at a more acidic intracellular pH. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Leukocyte Biology | - |
dc.subject | metabolism | - |
dc.subject | oxygen radicals | - |
dc.subject | butyrates | - |
dc.subject | calorimetry | - |
dc.subject | hydrogen ion concentration | - |
dc.subject | phagocytes | - |
dc.title | Intracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 1846905 | - |
dc.identifier.scopus | eid_2-s2.0-0025857502 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 180 | - |
dc.identifier.epage | 188 | - |
dc.identifier.isi | WOS:A1991ET88900009 | - |
dc.identifier.issnl | 0741-5400 | - |