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Article: Intracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria

TitleIntracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria
Authors
Keywordsmetabolism
oxygen radicals
butyrates
calorimetry
hydrogen ion concentration
phagocytes
Issue Date1991
Citation
Journal of Leukocyte Biology, 1991, v. 49, n. 2, p. 180-188 How to Cite?
AbstractThe effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso-butyric, on neutrophil metabolic activation were assessed. SCCA-induced a significant decrease in O 2· - recovery and chemiluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl-phorbol-acetate (TPA). SCCA did not alter O 2 consumption, H 2O 2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pH(i)). These results are consistent with an increased divalent versus univalent O 2 reduction performed by the NADPH oxidase at a more acidic intracellular pH.
Persistent Identifierhttp://hdl.handle.net/10722/230647
ISSN
2015 Impact Factor: 4.165
2015 SCImago Journal Rankings: 2.463

 

DC FieldValueLanguage
dc.contributor.authorTonetti, M.-
dc.contributor.authorCavallero, A.-
dc.contributor.authorBotta, G. A.-
dc.contributor.authorNiederman, R.-
dc.contributor.authorEftimiadi, C.-
dc.date.accessioned2016-09-01T06:06:27Z-
dc.date.available2016-09-01T06:06:27Z-
dc.date.issued1991-
dc.identifier.citationJournal of Leukocyte Biology, 1991, v. 49, n. 2, p. 180-188-
dc.identifier.issn0741-5400-
dc.identifier.urihttp://hdl.handle.net/10722/230647-
dc.description.abstractThe effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso-butyric, on neutrophil metabolic activation were assessed. SCCA-induced a significant decrease in O 2· - recovery and chemiluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl-phorbol-acetate (TPA). SCCA did not alter O 2 consumption, H 2O 2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pH(i)). These results are consistent with an increased divalent versus univalent O 2 reduction performed by the NADPH oxidase at a more acidic intracellular pH.-
dc.languageeng-
dc.relation.ispartofJournal of Leukocyte Biology-
dc.subjectmetabolism-
dc.subjectoxygen radicals-
dc.subjectbutyrates-
dc.subjectcalorimetry-
dc.subjecthydrogen ion concentration-
dc.subjectphagocytes-
dc.titleIntracellular pH regulates the production of different oxygen metabolites in neutrophils: Effects of organic acids produced by anaerobic bacteria-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid1846905-
dc.identifier.scopuseid_2-s2.0-0025857502-
dc.identifier.volume49-
dc.identifier.issue2-
dc.identifier.spage180-
dc.identifier.epage188-

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