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Article: Receptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs

TitleReceptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs
Authors
KeywordsCell movement
Hydrogen-ion concentration
Cytoskeleton
Granulocyte
Issue Date1990
Citation
BBA - Molecular Cell Research, 1990, v. 1054, n. 2, p. 154-158 How to Cite?
AbstractCytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells. © 1990.
Persistent Identifierhttp://hdl.handle.net/10722/230644
ISSN
2015 Impact Factor: 5.128
2015 SCImago Journal Rankings: 3.043

 

DC FieldValueLanguage
dc.contributor.authorTonetti, Maurizio-
dc.contributor.authorBudnick, Michael-
dc.contributor.authorNiederman, Richard-
dc.date.accessioned2016-09-01T06:06:27Z-
dc.date.available2016-09-01T06:06:27Z-
dc.date.issued1990-
dc.identifier.citationBBA - Molecular Cell Research, 1990, v. 1054, n. 2, p. 154-158-
dc.identifier.issn0167-4889-
dc.identifier.urihttp://hdl.handle.net/10722/230644-
dc.description.abstractCytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells. © 1990.-
dc.languageeng-
dc.relation.ispartofBBA - Molecular Cell Research-
dc.subjectCell movement-
dc.subjectHydrogen-ion concentration-
dc.subjectCytoskeleton-
dc.subjectGranulocyte-
dc.titleReceptor-stimulated actin polymerization requires cytoplasmic acidification in human PMNs-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0167-4889(90)90236-7-
dc.identifier.pmid2400780-
dc.identifier.scopuseid_2-s2.0-0025041540-
dc.identifier.volume1054-
dc.identifier.issue2-
dc.identifier.spage154-
dc.identifier.epage158-

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