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Article: Characterizing the malignancy and drug resistance of cancer cells from their membrane resealing response

TitleCharacterizing the malignancy and drug resistance of cancer cells from their membrane resealing response
Authors
Issue Date2016
PublisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2016, v. 6, p. article no. 26692 How to Cite?
AbstractIn this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, membrane pores in a number of pairs of cancer and normal cell lines originated from nasopharynx, lung and intestine were introduced by nano-mechanical puncturing. Interestingly, such nanometer-sized holes in tumor cells can reseal ∼ 2-3 times faster than those in the corresponding normal cells. Furthermore, the membrane resealing time in cancer cell lines exhibiting resistance to several leading chemotherapeutic drugs was also found to be substantially shorter than that in their drug-sensitive counterparts, demonstrating the potential of using this quantity as a novel marker for future cancer diagnosis and drug resistance detection. Finally, a simple model was proposed to explain the observed resealing dynamics of cells which suggested that the distinct response exhibited by normal, tumor and drug resistant cells is likely due to the different tension levels in their lipid membranes, a conclusion that is also supported by direct cortical tension measurement.
Persistent Identifierhttp://hdl.handle.net/10722/229268
ISSN
2015 Impact Factor: 5.228
2015 SCImago Journal Rankings: 2.073
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHUI, TH-
dc.contributor.authorZHOU, Z-
dc.contributor.authorFong, HW-
dc.contributor.authorNgan, KC-
dc.contributor.authorLee, TY-
dc.contributor.authorAu, SK-
dc.contributor.authorNgan, AHW-
dc.contributor.authorYip, TTC-
dc.contributor.authorLin, Y-
dc.date.accessioned2016-08-23T14:10:00Z-
dc.date.available2016-08-23T14:10:00Z-
dc.date.issued2016-
dc.identifier.citationScientific Reports, 2016, v. 6, p. article no. 26692-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/229268-
dc.description.abstractIn this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, membrane pores in a number of pairs of cancer and normal cell lines originated from nasopharynx, lung and intestine were introduced by nano-mechanical puncturing. Interestingly, such nanometer-sized holes in tumor cells can reseal ∼ 2-3 times faster than those in the corresponding normal cells. Furthermore, the membrane resealing time in cancer cell lines exhibiting resistance to several leading chemotherapeutic drugs was also found to be substantially shorter than that in their drug-sensitive counterparts, demonstrating the potential of using this quantity as a novel marker for future cancer diagnosis and drug resistance detection. Finally, a simple model was proposed to explain the observed resealing dynamics of cells which suggested that the distinct response exhibited by normal, tumor and drug resistant cells is likely due to the different tension levels in their lipid membranes, a conclusion that is also supported by direct cortical tension measurement.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleCharacterizing the malignancy and drug resistance of cancer cells from their membrane resealing response-
dc.typeArticle-
dc.identifier.emailNgan, AHW: hwngan@hku.hk-
dc.identifier.emailLin, Y: ylin@hkucc.hku.hk-
dc.identifier.authorityNgan, AHW=rp00225-
dc.identifier.authorityLin, Y=rp00080-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep26692-
dc.identifier.pmcidPMC4880901-
dc.identifier.scopuseid_2-s2.0-84971350442-
dc.identifier.hkuros261875-
dc.identifier.volume6-
dc.identifier.spagearticle no. 26692-
dc.identifier.epagearticle no. 26692-
dc.publisher.placeUnited Kingdom-

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