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Article: Optical Time Stretch for High-Speed and High-Throughput Imaging—From Single-Cell to Tissue-Wide Scales

TitleOptical Time Stretch for High-Speed and High-Throughput Imaging—From Single-Cell to Tissue-Wide Scales
Authors
Issue Date2015
PublisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=2944
Citation
IEEE Journal of Selected Topics in Quantum Electronics, 2015, v. 22 n. 4, p. article no. 6803115 How to Cite?
AbstractInitially developed for high-speed optical communica- tion, optical time stretch has recently been adopted for ultrafast and sensitive optical imaging at an unprecedented speed. In this paper, we highlight the essential concepts as well as the enabling elements of this ultrafast technology. More importantly, we review the re- cent developments of optical time-stretch imaging, especially in the context of 1) quantitative optofluidic microscopy for high-content single-cell phenotyping at an imaging throughput ∼100 000 cells/s; 2) all-optical multi-MHz (>10 MHz) swept-source optical coher- ence tomography (OCT) for high-speed in vivo anatomical and functional 3-D tissue imaging. We also discuss the current techno- logical challenges in time-stretch imaging. In particular, generating the enormous data in real time, this technology could uniquely cre- ate new insights of data-driven science in clinical diagnostics and basic biological research.
Persistent Identifierhttp://hdl.handle.net/10722/229200
ISSN
2015 Impact Factor: 3.466
2015 SCImago Journal Rankings: 1.632

 

DC FieldValueLanguage
dc.contributor.authorLau, KSA-
dc.contributor.authorTang, HL-
dc.contributor.authorXu, J-
dc.contributor.authorWei, X-
dc.contributor.authorWong, KKY-
dc.contributor.authorTsia, KKM-
dc.date.accessioned2016-08-23T14:09:36Z-
dc.date.available2016-08-23T14:09:36Z-
dc.date.issued2015-
dc.identifier.citationIEEE Journal of Selected Topics in Quantum Electronics, 2015, v. 22 n. 4, p. article no. 6803115-
dc.identifier.issn1077-260X-
dc.identifier.urihttp://hdl.handle.net/10722/229200-
dc.description.abstractInitially developed for high-speed optical communica- tion, optical time stretch has recently been adopted for ultrafast and sensitive optical imaging at an unprecedented speed. In this paper, we highlight the essential concepts as well as the enabling elements of this ultrafast technology. More importantly, we review the re- cent developments of optical time-stretch imaging, especially in the context of 1) quantitative optofluidic microscopy for high-content single-cell phenotyping at an imaging throughput ∼100 000 cells/s; 2) all-optical multi-MHz (>10 MHz) swept-source optical coher- ence tomography (OCT) for high-speed in vivo anatomical and functional 3-D tissue imaging. We also discuss the current techno- logical challenges in time-stretch imaging. In particular, generating the enormous data in real time, this technology could uniquely cre- ate new insights of data-driven science in clinical diagnostics and basic biological research.-
dc.languageeng-
dc.publisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=2944-
dc.relation.ispartofIEEE Journal of Selected Topics in Quantum Electronics-
dc.rightsIEEE Journal of Selected Topics in Quantum Electronics. Copyright © IEEE.-
dc.rights©20xx IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. -
dc.titleOptical Time Stretch for High-Speed and High-Throughput Imaging—From Single-Cell to Tissue-Wide Scales-
dc.typeArticle-
dc.identifier.emailLau, KSA: kslau718@hku.hk-
dc.identifier.emailWei, X: xmwei@hku.hk-
dc.identifier.emailWong, KKY: kywong@eee.hku.hk-
dc.identifier.emailTsia, KKM: tsia@hku.hk-
dc.identifier.authorityWong, KKY=rp00189-
dc.identifier.authorityTsia, KKM=rp01389-
dc.identifier.doi10.1109/JSTQE.2015.2512978-
dc.identifier.hkuros262133-
dc.identifier.volume22-
dc.identifier.issue4-
dc.identifier.spagearticle no. 6803115-
dc.identifier.epagearticle no. 6803115-
dc.publisher.placeUnited States-

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