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Conference Paper: The depigmenting effect and mechanism S of Kuwanon O and Sanggenon T from the roots of Morus australis

TitleThe depigmenting effect and mechanism S of Kuwanon O and Sanggenon T from the roots of Morus australis
Authors
Issue Date2015
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html
Citation
The 2015 Annual Meeting of the American Society of Pharmacognosy (ASP 2015), Copper Mountain, CO., 25-29 July 2015. In Planta Medica, 2015, v. 81 n. 11, PW14 How to Cite?
AbstractKuwanon O and sanggenon T, two resorcinol-type polyphenols from the root extract of Morus australis, were found to reveal significant depigmenting effects in both murine b16f10 and melan-a cell lines. But their depigmenting mechanisms are slightly different in two cell systems. In b16 cells, kuwanon O and sanggenon T, together with other two phenolics, induced post-transcriptional degradations of MITF without suppressing its mRNA expression, leading to significant decreases of TRP-1 and TRP-2 production. While in melan-a cells, the levels of tyrosinase families were suppressed via MITF downregulation at both transcription and translation level by them, with kuwanon O inducing the greatest suppression. Further evaluations in artificial skin model demonstrated the outstanding depigmenting effects of kuwanon O and sanggenon T. Meanwhile, according to the structure-activity relationship study of theses compounds, to screen or synthesize resorcinol flavonone derivatives with isoprenyl group in the Diels-Alder substituent might be a new direction for the search of potent hypopigmenting agents.
DescriptionConference Theme: Natural Products Rising to the Top
Poster Presentation: no. 3019
Persistent Identifierhttp://hdl.handle.net/10722/228906
ISSN
2015 Impact Factor: 1.99
2015 SCImago Journal Rankings: 0.702

 

DC FieldValueLanguage
dc.contributor.authorWang, M-
dc.contributor.authorHu, S-
dc.date.accessioned2016-08-23T14:07:46Z-
dc.date.available2016-08-23T14:07:46Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Annual Meeting of the American Society of Pharmacognosy (ASP 2015), Copper Mountain, CO., 25-29 July 2015. In Planta Medica, 2015, v. 81 n. 11, PW14-
dc.identifier.issn0032-0943-
dc.identifier.urihttp://hdl.handle.net/10722/228906-
dc.descriptionConference Theme: Natural Products Rising to the Top-
dc.descriptionPoster Presentation: no. 3019-
dc.description.abstractKuwanon O and sanggenon T, two resorcinol-type polyphenols from the root extract of Morus australis, were found to reveal significant depigmenting effects in both murine b16f10 and melan-a cell lines. But their depigmenting mechanisms are slightly different in two cell systems. In b16 cells, kuwanon O and sanggenon T, together with other two phenolics, induced post-transcriptional degradations of MITF without suppressing its mRNA expression, leading to significant decreases of TRP-1 and TRP-2 production. While in melan-a cells, the levels of tyrosinase families were suppressed via MITF downregulation at both transcription and translation level by them, with kuwanon O inducing the greatest suppression. Further evaluations in artificial skin model demonstrated the outstanding depigmenting effects of kuwanon O and sanggenon T. Meanwhile, according to the structure-activity relationship study of theses compounds, to screen or synthesize resorcinol flavonone derivatives with isoprenyl group in the Diels-Alder substituent might be a new direction for the search of potent hypopigmenting agents.-
dc.languageeng-
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html-
dc.relation.ispartofPlanta Medica-
dc.rightsPlanta Medica. Copyright © Georg Thieme Verlag.-
dc.titleThe depigmenting effect and mechanism S of Kuwanon O and Sanggenon T from the roots of Morus australis-
dc.typeConference_Paper-
dc.identifier.emailWang, M: mfwang@hku.hk-
dc.identifier.authorityWang, M=rp00800-
dc.identifier.doi10.1055/s-0035-1556442-
dc.identifier.hkuros261332-
dc.identifier.volume81-
dc.identifier.issue11, PW14-
dc.publisher.placeGermany-

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