File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Plasma sodium and subclinical left atrial enlargement in chronic kidney disease

TitlePlasma sodium and subclinical left atrial enlargement in chronic kidney disease
Authors
KeywordsChronic kidney disease
Issue Date2013
Citation
Nephrology Dialysis Transplantation, 2013, v. 28, n. 9, p. 2319-2328 How to Cite?
AbstractBackground. Left atrial enlargement (LAE) reflects diastolic dysfunction and predicts mortality in end-stage renal disease patients. However, little is known of its prevalence and factors associated with subclinical LAE in earlier stages of chronic kidney disease (CKD). Methods. We conducted a prospective, cross-sectional study in 261 Stage 3-5 non-dialysis CKD patients without symptomatic cardiovascular disease with two-dimensional echocardiography performed to estimate left atrial volume index and other cardiac parameters. Results. One hundred and nine (41.8%) patients had LAE. Mild and moderate/severe LAEs were observed in 22.9 and 41.3% of patients with left ventricular (LV) hypertrophy (n = 109) versus 13.2 and 12.5% of patients with no LV hypertrophy (n = 152), respectively (P < 0.001). On univariate analysis, plasma sodium concentration showed a significant association with LAE [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.09-1.37; P = 0.001]. In the stepwise multiple logistic regression, plasma sodium concentration emerged as one of the most significant factors associated with LAE (adjusted OR 1.29, 95% CI 1.14-1.47; P < 0.001]. Its significance was well maintained (adjusted OR 1.23, 95% CI 1.07-1.43; P = 0.005) when including LV mass and volume index and N-terminal pro-brain natriuretic peptide in the model, while blood haemoglobin and systolic blood pressure were displaced. Conclusions. This study for the first time alerted to a very high prevalence of subclinical LAE and reported a strong novel, independent relationship between plasma sodium concentration and subclinical LAE in Stage 3-5 CKD patients. Longitudinal studies are needed to establish causality between high plasma sodium concentration and LAE and their usefulness as therapeutic targets in CKD. © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA.
Persistent Identifierhttp://hdl.handle.net/10722/228476
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 1.780

 

DC FieldValueLanguage
dc.contributor.authorWang, Angela Yee Moon-
dc.contributor.authorLu, Ye-
dc.contributor.authorCheung, Sharon-
dc.contributor.authorChan, Iris Hiu Shuen-
dc.contributor.authorLam, Christopher Wai Kei-
dc.date.accessioned2016-08-13T08:02:30Z-
dc.date.available2016-08-13T08:02:30Z-
dc.date.issued2013-
dc.identifier.citationNephrology Dialysis Transplantation, 2013, v. 28, n. 9, p. 2319-2328-
dc.identifier.issn0931-0509-
dc.identifier.urihttp://hdl.handle.net/10722/228476-
dc.description.abstractBackground. Left atrial enlargement (LAE) reflects diastolic dysfunction and predicts mortality in end-stage renal disease patients. However, little is known of its prevalence and factors associated with subclinical LAE in earlier stages of chronic kidney disease (CKD). Methods. We conducted a prospective, cross-sectional study in 261 Stage 3-5 non-dialysis CKD patients without symptomatic cardiovascular disease with two-dimensional echocardiography performed to estimate left atrial volume index and other cardiac parameters. Results. One hundred and nine (41.8%) patients had LAE. Mild and moderate/severe LAEs were observed in 22.9 and 41.3% of patients with left ventricular (LV) hypertrophy (n = 109) versus 13.2 and 12.5% of patients with no LV hypertrophy (n = 152), respectively (P < 0.001). On univariate analysis, plasma sodium concentration showed a significant association with LAE [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.09-1.37; P = 0.001]. In the stepwise multiple logistic regression, plasma sodium concentration emerged as one of the most significant factors associated with LAE (adjusted OR 1.29, 95% CI 1.14-1.47; P < 0.001]. Its significance was well maintained (adjusted OR 1.23, 95% CI 1.07-1.43; P = 0.005) when including LV mass and volume index and N-terminal pro-brain natriuretic peptide in the model, while blood haemoglobin and systolic blood pressure were displaced. Conclusions. This study for the first time alerted to a very high prevalence of subclinical LAE and reported a strong novel, independent relationship between plasma sodium concentration and subclinical LAE in Stage 3-5 CKD patients. Longitudinal studies are needed to establish causality between high plasma sodium concentration and LAE and their usefulness as therapeutic targets in CKD. © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA.-
dc.languageeng-
dc.relation.ispartofNephrology Dialysis Transplantation-
dc.subjectChronic kidney disease-
dc.titlePlasma sodium and subclinical left atrial enlargement in chronic kidney disease-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ndt/gfs588-
dc.identifier.pmid23314317-
dc.identifier.scopuseid_2-s2.0-84884521753-
dc.identifier.volume28-
dc.identifier.issue9-
dc.identifier.spage2319-
dc.identifier.epage2328-
dc.identifier.eissn1460-2385-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats