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Article: Prevention and treatment of protein energy wasting in chronic kidney disease patients: A consensus statement by the International Society of Renal Nutrition and Metabolism

TitlePrevention and treatment of protein energy wasting in chronic kidney disease patients: A consensus statement by the International Society of Renal Nutrition and Metabolism
Authors
Keywordsdialysis
Issue Date2013
Citation
Kidney International, 2013, v. 84, n. 6, p. 1096-1107 How to Cite?
AbstractProtein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes, especially in individuals receiving maintenance dialysis therapy. A multitude of factors can affect the nutritional and metabolic status of CKD patients requiring a combination of therapeutic maneuvers to prevent or reverse protein and energy depletion. These include optimizing dietary nutrient intake, appropriate treatment of metabolic disturbances such as metabolic acidosis, systemic inflammation, and hormonal deficiencies, and prescribing optimized dialytic regimens. In patients where oral dietary intake from regular meals cannot maintain adequate nutritional status, nutritional supplementation, administered orally, enterally, or parenterally, is shown to be effective in replenishing protein and energy stores. In clinical practice, the advantages of oral nutritional supplements include proven efficacy, safety, and compliance. Anabolic strategies such as anabolic steroids, growth hormone, and exercise, in combination with nutritional supplementation or alone, have been shown to improve protein stores and represent potential additional approaches for the treatment of PEW. Appetite stimulants, anti-inflammatory interventions, and newer anabolic agents are emerging as novel therapies. While numerous epidemiological data suggest that an improvement in biomarkers of nutritional status is associated with improved survival, there are no large randomized clinical trials that have tested the effectiveness of nutritional interventions on mortality and morbidity.© 2013 International Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/228472
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181

 

DC FieldValueLanguage
dc.contributor.authorIkizler, T. Alp-
dc.contributor.authorCano, Noel J.-
dc.contributor.authorFranch, Harold-
dc.contributor.authorFouque, Denis-
dc.contributor.authorHimmelfarb, Jonathan-
dc.contributor.authorKalantar-Zadeh, Kamyar-
dc.contributor.authorKuhlmann, Martin K.-
dc.contributor.authorStenvinkel, Peter-
dc.contributor.authorTerwee, Pieter-
dc.contributor.authorTeta, Daniel-
dc.contributor.authorWang, Angela Yee Moon-
dc.contributor.authorWanner, Christoph-
dc.date.accessioned2016-08-13T08:02:30Z-
dc.date.available2016-08-13T08:02:30Z-
dc.date.issued2013-
dc.identifier.citationKidney International, 2013, v. 84, n. 6, p. 1096-1107-
dc.identifier.issn0085-2538-
dc.identifier.urihttp://hdl.handle.net/10722/228472-
dc.description.abstractProtein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes, especially in individuals receiving maintenance dialysis therapy. A multitude of factors can affect the nutritional and metabolic status of CKD patients requiring a combination of therapeutic maneuvers to prevent or reverse protein and energy depletion. These include optimizing dietary nutrient intake, appropriate treatment of metabolic disturbances such as metabolic acidosis, systemic inflammation, and hormonal deficiencies, and prescribing optimized dialytic regimens. In patients where oral dietary intake from regular meals cannot maintain adequate nutritional status, nutritional supplementation, administered orally, enterally, or parenterally, is shown to be effective in replenishing protein and energy stores. In clinical practice, the advantages of oral nutritional supplements include proven efficacy, safety, and compliance. Anabolic strategies such as anabolic steroids, growth hormone, and exercise, in combination with nutritional supplementation or alone, have been shown to improve protein stores and represent potential additional approaches for the treatment of PEW. Appetite stimulants, anti-inflammatory interventions, and newer anabolic agents are emerging as novel therapies. While numerous epidemiological data suggest that an improvement in biomarkers of nutritional status is associated with improved survival, there are no large randomized clinical trials that have tested the effectiveness of nutritional interventions on mortality and morbidity.© 2013 International Society of Nephrology.-
dc.languageeng-
dc.relation.ispartofKidney International-
dc.subjectdialysis-
dc.titlePrevention and treatment of protein energy wasting in chronic kidney disease patients: A consensus statement by the International Society of Renal Nutrition and Metabolism-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ki.2013.147-
dc.identifier.pmid23698226-
dc.identifier.scopuseid_2-s2.0-84876713791-
dc.identifier.volume84-
dc.identifier.issue6-
dc.identifier.spage1096-
dc.identifier.epage1107-
dc.identifier.eissn1523-1755-

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