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Article: Serum small-dense LDL abnormalities in chronic renal disease patients

TitleSerum small-dense LDL abnormalities in chronic renal disease patients
Authors
KeywordsKidney diseases
Issue Date2012
Citation
British Journal of Biomedical Science, 2012, v. 69, n. 3, p. 99-102 How to Cite?
AbstractCardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Dyslipoproteinaemia is a common metabolic derangement in CKD and a traditional risk factor for CVD. This study investigates serum lipoprotein, especially small-dense lowdensity lipoprotein (sd-LDL), abnormalities in CKD patients. A total of 131 CKD patients (age: 59±12 years, male=64) diagnosed according to Kidney Disease: Improving Global Outcomes, 2004 (KDIGO) and 121 ageand gender-matched control subjects (age: 58±6 years, male=62) were recruited from Hong Kong and Macau. Serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C) and direct LDL-C were assayed enzymatically. In addition, sd-LDL, together with very low density and intermediate-density lipoproteins (VLDL and IDL) were measured by US Food and Drug Administration (FDA)-approved polyacrylamide gradient gel electrophoresis. Compared to controls, CKD patients showed significantly decreased TC, LDL-C, normal-size LDL and HDL-C with increased TG, VLDL, IDL and sd-LDL (all P<0.01). The increased sd-LDL and decreased normal-size LDL fractions resulted in a significantly elevated sd-LDL:LDL ratio in CKD (P<0.005). In contrast to the low TC and LDL-C, sd-LDL and sd- LDL:LDL ratio were significantly elevated in CKD. Thus, sd-LDL will be used increasingly for CVD risk assessment in CKD and other diseases that show lipoprotein derangement.
Persistent Identifierhttp://hdl.handle.net/10722/228470
ISSN
2015 Impact Factor: 1.245
2015 SCImago Journal Rankings: 0.352

 

DC FieldValueLanguage
dc.contributor.authorChu, M.-
dc.contributor.authorWang, A. Y M-
dc.contributor.authorChan, I. H S-
dc.contributor.authorChui, S. H.-
dc.contributor.authorLam, C. W K-
dc.date.accessioned2016-08-13T08:02:29Z-
dc.date.available2016-08-13T08:02:29Z-
dc.date.issued2012-
dc.identifier.citationBritish Journal of Biomedical Science, 2012, v. 69, n. 3, p. 99-102-
dc.identifier.issn0967-4845-
dc.identifier.urihttp://hdl.handle.net/10722/228470-
dc.description.abstractCardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Dyslipoproteinaemia is a common metabolic derangement in CKD and a traditional risk factor for CVD. This study investigates serum lipoprotein, especially small-dense lowdensity lipoprotein (sd-LDL), abnormalities in CKD patients. A total of 131 CKD patients (age: 59±12 years, male=64) diagnosed according to Kidney Disease: Improving Global Outcomes, 2004 (KDIGO) and 121 ageand gender-matched control subjects (age: 58±6 years, male=62) were recruited from Hong Kong and Macau. Serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C) and direct LDL-C were assayed enzymatically. In addition, sd-LDL, together with very low density and intermediate-density lipoproteins (VLDL and IDL) were measured by US Food and Drug Administration (FDA)-approved polyacrylamide gradient gel electrophoresis. Compared to controls, CKD patients showed significantly decreased TC, LDL-C, normal-size LDL and HDL-C with increased TG, VLDL, IDL and sd-LDL (all P<0.01). The increased sd-LDL and decreased normal-size LDL fractions resulted in a significantly elevated sd-LDL:LDL ratio in CKD (P<0.005). In contrast to the low TC and LDL-C, sd-LDL and sd- LDL:LDL ratio were significantly elevated in CKD. Thus, sd-LDL will be used increasingly for CVD risk assessment in CKD and other diseases that show lipoprotein derangement.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Biomedical Science-
dc.subjectKidney diseases-
dc.titleSerum small-dense LDL abnormalities in chronic renal disease patients-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid23057155-
dc.identifier.scopuseid_2-s2.0-84868636737-
dc.identifier.volume69-
dc.identifier.issue3-
dc.identifier.spage99-
dc.identifier.epage102-

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