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Article: Heart failure in long-term peritoneal dialysis patients: A 4-Year prospective analysis

TitleHeart failure in long-term peritoneal dialysis patients: A 4-Year prospective analysis
Authors
Issue Date2011
Citation
Clinical Journal of the American Society of Nephrology, 2011, v. 6, n. 4, p. 805-812 How to Cite?
AbstractBackground and objectives Heart failure occurs frequently in end-stage renal disease patients. However, there are no prospective, longitudinal follow-up data on its prevalence, severity, and risk factors in long-term peritoneal dialysis (PD) patients. Design, setting, participants, & measurements A prospective observational study was conducted in 220 long-term PD patients followed up for 4 years or until death. Echocardiography was obtained at baseline. Primary study end points were heart failure and mortality. Results Eighty-six patients had a previous history of heart failure at study entry. The cumulative 4-year survival probability was 37.4% and 64.7% for patients with and without previous heart failure, respectively (P < 0.0001). During follow-up, 87 patients (40.9%) developed heart failure, of which 53 were recurrence and 34 were new-onset heart failure. Diabetes, background atherosclerotic vascular disease, systolic hypertension, left ventricular (LV) mass index, systolic dysfunction, and hypoalbuminemia were significant risk factors predicting heart failure in the entire cohort. Diabetes and LV mass and volume index were significant predictors of new-onset heart failure. Systolic hypertension, LV volume index, and hypoalbuminemia were significant predictors of recurrent heart failure. Conclusions Heart failure is a highly prevalent complication in long-term PD patients and predicts adverse clinical outcomes. More attention should be focused on improving BP and volume control and identifying treatment strategies that effectively lower atherosclerotic burden and reverse LV hypertrophy, remodeling, and systolic dysfunction in PD patients. © 2011 by the American Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/228464
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.534

 

DC FieldValueLanguage
dc.contributor.authorWang, Angela Yee Moon-
dc.contributor.authorWang, Mei-
dc.contributor.authorLam, Christopher Wai Kei-
dc.contributor.authorChan, Iris Hiu Shuen-
dc.contributor.authorLui, Siu Fai-
dc.contributor.authorSanderson, John E.-
dc.date.accessioned2016-08-13T08:02:28Z-
dc.date.available2016-08-13T08:02:28Z-
dc.date.issued2011-
dc.identifier.citationClinical Journal of the American Society of Nephrology, 2011, v. 6, n. 4, p. 805-812-
dc.identifier.issn1555-9041-
dc.identifier.urihttp://hdl.handle.net/10722/228464-
dc.description.abstractBackground and objectives Heart failure occurs frequently in end-stage renal disease patients. However, there are no prospective, longitudinal follow-up data on its prevalence, severity, and risk factors in long-term peritoneal dialysis (PD) patients. Design, setting, participants, & measurements A prospective observational study was conducted in 220 long-term PD patients followed up for 4 years or until death. Echocardiography was obtained at baseline. Primary study end points were heart failure and mortality. Results Eighty-six patients had a previous history of heart failure at study entry. The cumulative 4-year survival probability was 37.4% and 64.7% for patients with and without previous heart failure, respectively (P < 0.0001). During follow-up, 87 patients (40.9%) developed heart failure, of which 53 were recurrence and 34 were new-onset heart failure. Diabetes, background atherosclerotic vascular disease, systolic hypertension, left ventricular (LV) mass index, systolic dysfunction, and hypoalbuminemia were significant risk factors predicting heart failure in the entire cohort. Diabetes and LV mass and volume index were significant predictors of new-onset heart failure. Systolic hypertension, LV volume index, and hypoalbuminemia were significant predictors of recurrent heart failure. Conclusions Heart failure is a highly prevalent complication in long-term PD patients and predicts adverse clinical outcomes. More attention should be focused on improving BP and volume control and identifying treatment strategies that effectively lower atherosclerotic burden and reverse LV hypertrophy, remodeling, and systolic dysfunction in PD patients. © 2011 by the American Society of Nephrology.-
dc.languageeng-
dc.relation.ispartofClinical Journal of the American Society of Nephrology-
dc.titleHeart failure in long-term peritoneal dialysis patients: A 4-Year prospective analysis-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.2215/CJN.07130810-
dc.identifier.pmid21212423-
dc.identifier.scopuseid_2-s2.0-79955563490-
dc.identifier.volume6-
dc.identifier.issue4-
dc.identifier.spage805-
dc.identifier.epage812-
dc.identifier.eissn1555-905X-

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