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Article: A screening strategy for the detection of sickle cell retinopathy in pediatric patients

TitleA screening strategy for the detection of sickle cell retinopathy in pediatric patients
Authors
KeywordsPediatric
Issue Date2008
Citation
Canadian Journal of Ophthalmology, 2008, v. 43, n. 2, p. 188-191 How to Cite?
AbstractBackground: Children with sickle cell hemoglobinopathy are referred routinely to detect retinopathy and thereby prevent vision-threatening complications. This study aimed to determine the prevalence and age of onset of clinically significant retinopathy in such patients, and to recommend a screening strategy for ophthalmologists. Methods: Two hundred sixty-three pediatric sickle cell patients to a maximum age of 18 years during the period of observation were reviewed for the onset of retinopathy, considering the influence of hemoglobin genotype, gender, and the presence of systemic manifestations. Results: Proliferative retinopathy (PR) was rare. Six cases (8.2%) of PR were seen in the SC genotype, I case (0.6%) in the SS genotype, and no cases in the SB-Thalassemia genotype. The age of onset of PR was a mean of 13.7 years (median 13, range 9-18) in the SC genotype and 16 years in the SS genotype. Neither gender nor the presence of systemic manifestations was predictive for the prevalence or age of onset of retinopathy. Interpretation: Screening for retinopathy may begin at age 9 years for SC genotype patients and at age 13 years for SS and SB-Thalassemia genotype patients. Serial examinations may be done biennially for eyes with normal findings. Patients with an abnormal examination should undergo fluorescein angiography and be followed as necessary.
Persistent Identifierhttp://hdl.handle.net/10722/228057
ISSN
2015 Impact Factor: 1.46
2015 SCImago Journal Rankings: 0.685

 

DC FieldValueLanguage
dc.contributor.authorGill, Harmeet S.-
dc.contributor.authorLam, Wai Ching-
dc.date.accessioned2016-08-01T06:45:05Z-
dc.date.available2016-08-01T06:45:05Z-
dc.date.issued2008-
dc.identifier.citationCanadian Journal of Ophthalmology, 2008, v. 43, n. 2, p. 188-191-
dc.identifier.issn0008-4182-
dc.identifier.urihttp://hdl.handle.net/10722/228057-
dc.description.abstractBackground: Children with sickle cell hemoglobinopathy are referred routinely to detect retinopathy and thereby prevent vision-threatening complications. This study aimed to determine the prevalence and age of onset of clinically significant retinopathy in such patients, and to recommend a screening strategy for ophthalmologists. Methods: Two hundred sixty-three pediatric sickle cell patients to a maximum age of 18 years during the period of observation were reviewed for the onset of retinopathy, considering the influence of hemoglobin genotype, gender, and the presence of systemic manifestations. Results: Proliferative retinopathy (PR) was rare. Six cases (8.2%) of PR were seen in the SC genotype, I case (0.6%) in the SS genotype, and no cases in the SB-Thalassemia genotype. The age of onset of PR was a mean of 13.7 years (median 13, range 9-18) in the SC genotype and 16 years in the SS genotype. Neither gender nor the presence of systemic manifestations was predictive for the prevalence or age of onset of retinopathy. Interpretation: Screening for retinopathy may begin at age 9 years for SC genotype patients and at age 13 years for SS and SB-Thalassemia genotype patients. Serial examinations may be done biennially for eyes with normal findings. Patients with an abnormal examination should undergo fluorescein angiography and be followed as necessary.-
dc.languageeng-
dc.relation.ispartofCanadian Journal of Ophthalmology-
dc.subjectPediatric-
dc.titleA screening strategy for the detection of sickle cell retinopathy in pediatric patients-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.3129/I08-003-
dc.identifier.scopuseid_2-s2.0-42049117333-
dc.identifier.volume43-
dc.identifier.issue2-
dc.identifier.spage188-
dc.identifier.epage191-
dc.identifier.eissn1715-3360-

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