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Article: Retinal arteriolar hemodynamic response to a combined isocapnic hyperoxia and glucose provocation in early sight-threatening diabetic retinopathy

TitleRetinal arteriolar hemodynamic response to a combined isocapnic hyperoxia and glucose provocation in early sight-threatening diabetic retinopathy
Authors
Issue Date2008
Citation
Investigative Ophthalmology and Visual Science, 2008, v. 49, n. 2, p. 699-705 How to Cite?
AbstractPurpose. To quantify the magnitude of change of retinal arteriolar hemodynamics induced by a combined isocapnic hyperoxia and glucose provocation in diabetic patients with early sight-threatening diabetic retinopathy (DR) and in age-matched control subjects and to compare the response to that of an isocapnic hyperoxia provocation alone. The study hypothesis was that hyperglycemia reduces the retinal vascular reactivity response to a hyperoxic stimulus. Methods. The sample comprised 17 control subjects (group 1), 15 patients with no clinically visible DR (group 2), 16 patients with mild-to-moderate nonproliferative DR (group 3), and 15 patients with diabetic macular edema (group 4). Retinal hemodynamic measurements were acquired in the subjects, at baseline and 1 hour after consuming a standardized oral glucose load drink while breathing oxygen isocapnic with baseline. Results. Retinal blood velocity and flow significantly decreased in all groups (P ≤ 0.001 and P ≤ 0.0002, respectively) in response to a combined isocapnic hyperoxia and glucose provocation. The maximum-to-minimum velocity ratio significantly increased (P ≤ 0.005), and wall shear rate (WSR) significantly decreased (P ≤ 0.0002), in groups 1, 2, and 3, but not in group 4. The vascular reactivity response was not significantly different across the groups. The control group demonstrated a reduced change in flow (P = 0.009) and WSR (P = 0.010) to the combined isocapnic hyperoxia and glucose provocation compared with that of hyperoxia alone. Conclusions. The vascular reactivity response to a combined isocapnic hyperoxia and glucose provocation produced a pronounced reduction in blood flow. Unlike the response to hyperoxia alone, the vascular reactivity response was not significantly different across the groups. Hyperglycemia reduced the retinal vascular reactivity response to hyperoxia in age-matched control subjects. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/228056
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008

 

DC FieldValueLanguage
dc.contributor.authorGilmore, Edward D.-
dc.contributor.authorHudson, Chris-
dc.contributor.authorNrusimhadevara, Ravi K.-
dc.contributor.authorRidout, Rowena-
dc.contributor.authorHarvey, Patricia T.-
dc.contributor.authorMandelcorn, Mark-
dc.contributor.authorLam, Wai Ching-
dc.contributor.authorDevenyi, Robert G.-
dc.date.accessioned2016-08-01T06:45:04Z-
dc.date.available2016-08-01T06:45:04Z-
dc.date.issued2008-
dc.identifier.citationInvestigative Ophthalmology and Visual Science, 2008, v. 49, n. 2, p. 699-705-
dc.identifier.issn0146-0404-
dc.identifier.urihttp://hdl.handle.net/10722/228056-
dc.description.abstractPurpose. To quantify the magnitude of change of retinal arteriolar hemodynamics induced by a combined isocapnic hyperoxia and glucose provocation in diabetic patients with early sight-threatening diabetic retinopathy (DR) and in age-matched control subjects and to compare the response to that of an isocapnic hyperoxia provocation alone. The study hypothesis was that hyperglycemia reduces the retinal vascular reactivity response to a hyperoxic stimulus. Methods. The sample comprised 17 control subjects (group 1), 15 patients with no clinically visible DR (group 2), 16 patients with mild-to-moderate nonproliferative DR (group 3), and 15 patients with diabetic macular edema (group 4). Retinal hemodynamic measurements were acquired in the subjects, at baseline and 1 hour after consuming a standardized oral glucose load drink while breathing oxygen isocapnic with baseline. Results. Retinal blood velocity and flow significantly decreased in all groups (P ≤ 0.001 and P ≤ 0.0002, respectively) in response to a combined isocapnic hyperoxia and glucose provocation. The maximum-to-minimum velocity ratio significantly increased (P ≤ 0.005), and wall shear rate (WSR) significantly decreased (P ≤ 0.0002), in groups 1, 2, and 3, but not in group 4. The vascular reactivity response was not significantly different across the groups. The control group demonstrated a reduced change in flow (P = 0.009) and WSR (P = 0.010) to the combined isocapnic hyperoxia and glucose provocation compared with that of hyperoxia alone. Conclusions. The vascular reactivity response to a combined isocapnic hyperoxia and glucose provocation produced a pronounced reduction in blood flow. Unlike the response to hyperoxia alone, the vascular reactivity response was not significantly different across the groups. Hyperglycemia reduced the retinal vascular reactivity response to hyperoxia in age-matched control subjects. Copyright © Association for Research in Vision and Ophthalmology.-
dc.languageeng-
dc.relation.ispartofInvestigative Ophthalmology and Visual Science-
dc.titleRetinal arteriolar hemodynamic response to a combined isocapnic hyperoxia and glucose provocation in early sight-threatening diabetic retinopathy-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1167/iovs.07-0339-
dc.identifier.pmid18235017-
dc.identifier.scopuseid_2-s2.0-40649116471-
dc.identifier.volume49-
dc.identifier.issue2-
dc.identifier.spage699-
dc.identifier.epage705-
dc.identifier.eissn1552-5783-

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