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Article: Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex

TitleSelective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex
Authors
KeywordsBaclofen
Issue Date1994
Citation
Brain Research, 1994, v. 659, n. 1-2, p. 75-81 How to Cite?
AbstractThe GABAB agonist baclofen has been shown to suppress synaptic transmission in subregions of the hippocampus and in the piriform (olfactory) cortex. Here we report a laminar selectivity of suppression of synaptic potentials in the olfactory cortex. In brain slice preparations, baclofen suppresses extracellularly recorded field potentials at the intrinsic fiber synapses proximal to the superficial pyramidal cell bodies (layer Ib) while leaving the af ferent fiber synaptic potentials recorded at the distal dendrites (layer Ia) little affected. This dose-dependent selective suppression of intrinsic fiber synaptic transmission is also correlated with an increase of paired-pulse facilitation. These results suggest that afferent and intrinsic synaptic inputs may be differentially modulated by the activation of GABAB receptors and that this selective suppression is at least partially mediated via a presynaptic mechanism. © 1994.
Persistent Identifierhttp://hdl.handle.net/10722/228000
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351

 

DC FieldValueLanguage
dc.contributor.authorTang, Akaysha C.-
dc.contributor.authorHasselmo, Michael E.-
dc.date.accessioned2016-08-01T06:44:56Z-
dc.date.available2016-08-01T06:44:56Z-
dc.date.issued1994-
dc.identifier.citationBrain Research, 1994, v. 659, n. 1-2, p. 75-81-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/10722/228000-
dc.description.abstractThe GABAB agonist baclofen has been shown to suppress synaptic transmission in subregions of the hippocampus and in the piriform (olfactory) cortex. Here we report a laminar selectivity of suppression of synaptic potentials in the olfactory cortex. In brain slice preparations, baclofen suppresses extracellularly recorded field potentials at the intrinsic fiber synapses proximal to the superficial pyramidal cell bodies (layer Ib) while leaving the af ferent fiber synaptic potentials recorded at the distal dendrites (layer Ia) little affected. This dose-dependent selective suppression of intrinsic fiber synaptic transmission is also correlated with an increase of paired-pulse facilitation. These results suggest that afferent and intrinsic synaptic inputs may be differentially modulated by the activation of GABAB receptors and that this selective suppression is at least partially mediated via a presynaptic mechanism. © 1994.-
dc.languageeng-
dc.relation.ispartofBrain Research-
dc.subjectBaclofen-
dc.titleSelective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0006-8993(94)90865-6-
dc.identifier.pmid7820683-
dc.identifier.scopuseid_2-s2.0-0027930791-
dc.identifier.volume659-
dc.identifier.issue1-2-
dc.identifier.spage75-
dc.identifier.epage81-

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