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Article: Individual Correlates of Infectivity of Influenza A Virus Infections in Households
Title | Individual Correlates of Infectivity of Influenza A Virus Infections in Households |
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Authors | |
Issue Date | 2016 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | Plos One, 2016, v. 11 n. 5, article no. e0154418 How to Cite? |
Abstract | Background
Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited.
Methods
In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity.
Results
We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group.
Conclusions
Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies. |
Persistent Identifier | http://hdl.handle.net/10722/227859 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsang, TK | - |
dc.contributor.author | Fang, VJ | - |
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.contributor.author | Cauchemez, S | - |
dc.date.accessioned | 2016-07-21T01:06:24Z | - |
dc.date.available | 2016-07-21T01:06:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Plos One, 2016, v. 11 n. 5, article no. e0154418 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10722/227859 | - |
dc.description.abstract | Background Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. Methods In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. Results We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. Conclusions Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies. | - |
dc.language | eng | - |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | - |
dc.relation.ispartof | PLoS ONE | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Individual Correlates of Infectivity of Influenza A Virus Infections in Households | - |
dc.type | Article | - |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.authority | Chan, KH=rp01921 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0154418 | - |
dc.identifier.pmid | 27153194 | - |
dc.identifier.pmcid | PMC4859516 | - |
dc.identifier.scopus | eid_2-s2.0-84969760086 | - |
dc.identifier.hkuros | 260249 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | article no. e0154418 | - |
dc.identifier.epage | article no. e0154418 | - |
dc.identifier.isi | WOS:000375677000018 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1932-6203 | - |