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Article: Individual Correlates of Infectivity of Influenza A Virus Infections in Households

TitleIndividual Correlates of Infectivity of Influenza A Virus Infections in Households
Authors
Issue Date2016
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2016, v. 11 n. 5, p. e0154418 How to Cite?
AbstractBackground Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. Methods In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. Results We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. Conclusions Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies.
Persistent Identifierhttp://hdl.handle.net/10722/227859
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, TK-
dc.contributor.authorFang, VJ-
dc.contributor.authorChan, KH-
dc.contributor.authorIp, DKM-
dc.contributor.authorLeung, GM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.contributor.authorCauchemez, S-
dc.date.accessioned2016-07-21T01:06:24Z-
dc.date.available2016-07-21T01:06:24Z-
dc.date.issued2016-
dc.identifier.citationPlos One, 2016, v. 11 n. 5, p. e0154418-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/227859-
dc.description.abstractBackground Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. Methods In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. Results We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. Conclusions Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPlos One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIndividual Correlates of Infectivity of Influenza A Virus Infections in Households-
dc.typeArticle-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0154418-
dc.identifier.pmid27153194-
dc.identifier.hkuros260249-
dc.identifier.volume11-
dc.identifier.issue5-
dc.identifier.spagee0154418-
dc.identifier.epagee0154418-
dc.identifier.isiWOS:000375677000018-
dc.publisher.placeUnited States-

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