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Article: Associations of pubertal stage and body mass index with cardiometabolic risk in Hong Kong Chinese children: A cross-sectional study

TitleAssociations of pubertal stage and body mass index with cardiometabolic risk in Hong Kong Chinese children: A cross-sectional study
Authors
Issue Date2015
PublisherBiomedCentral. The Journal's web site is located at http://www.biomedcentral.com/bmcpediatr/
Citation
BMC Pediatrics, 2015, v. 15, article no. 136 How to Cite?
AbstractBackground: Puberty is associated with a clustering of cardiometabolic risk factors (CMRFs) during adolescence that are manifested in later life. Although anthropometric variables such as body mass index (BMI) can predict cardiometabolic risk in children and adolescents, it is not clear whether there is an interaction between pubertal stage and BMI associated with cardiometabolic risk in this age group. This paper examines the association of pubertal stage and BMI with CMRFs in Hong Kong Chinese children. Methods: A cross-sectional school-based study was conducted among 1985 (95.1%) students aged 6 to 18 years. Fasting lipid profile and plasma glucose, blood pressure, body weight, body height and waist circumference were measured. A self-reported pubertal stage questionnaire was used to assess pubertal stage of participants. Two cardiometabolic risk scores, alpha and beta, were constructed to quantify cardiometabolic risk. Cardiometabolic risk score alpha refers to the sum of z-scores of sex-specific, age-adjusted waist circumference, height-adjusted systolic and diastolic blood pressure, fasting plasma glucose, triglyceride and low-density lipoprotein cholesterol, and minus z-score of sex-specific age-adjusted high-density lipoprotein cholesterol. Cardiometabolic risk score beta includes all components of risk score alpha except waist circumference. Results: The interaction of BMI z-score (ZBMI) and pubertal stage demonstrated a significant increase in variance explained in cardiometabolic risk score alpha in boys (0.5%, p = 0.024) and girls (0.7%, p = 0.006) and in cardiometabolic risk score beta in boys (0.8%, p = 0.030) but not in girls (0.5%, p = 0.051). Conclusions: Pubertal stage has an interaction effect on the association of cardiometabolic risk by BMI in boys and may have a similar but lesser effect in girls.
Persistent Identifierhttp://hdl.handle.net/10722/227558

 

DC FieldValueLanguage
dc.contributor.authorChan, PT-
dc.contributor.authorChoi, KC-
dc.contributor.authorNelson, E ANTHONY-
dc.contributor.authorChan, JULIANA C-
dc.contributor.authorKong, ALICE PS-
dc.date.accessioned2016-07-18T09:11:27Z-
dc.date.available2016-07-18T09:11:27Z-
dc.date.issued2015-
dc.identifier.citationBMC Pediatrics, 2015, v. 15, article no. 136-
dc.identifier.urihttp://hdl.handle.net/10722/227558-
dc.description.abstractBackground: Puberty is associated with a clustering of cardiometabolic risk factors (CMRFs) during adolescence that are manifested in later life. Although anthropometric variables such as body mass index (BMI) can predict cardiometabolic risk in children and adolescents, it is not clear whether there is an interaction between pubertal stage and BMI associated with cardiometabolic risk in this age group. This paper examines the association of pubertal stage and BMI with CMRFs in Hong Kong Chinese children. Methods: A cross-sectional school-based study was conducted among 1985 (95.1%) students aged 6 to 18 years. Fasting lipid profile and plasma glucose, blood pressure, body weight, body height and waist circumference were measured. A self-reported pubertal stage questionnaire was used to assess pubertal stage of participants. Two cardiometabolic risk scores, alpha and beta, were constructed to quantify cardiometabolic risk. Cardiometabolic risk score alpha refers to the sum of z-scores of sex-specific, age-adjusted waist circumference, height-adjusted systolic and diastolic blood pressure, fasting plasma glucose, triglyceride and low-density lipoprotein cholesterol, and minus z-score of sex-specific age-adjusted high-density lipoprotein cholesterol. Cardiometabolic risk score beta includes all components of risk score alpha except waist circumference. Results: The interaction of BMI z-score (ZBMI) and pubertal stage demonstrated a significant increase in variance explained in cardiometabolic risk score alpha in boys (0.5%, p = 0.024) and girls (0.7%, p = 0.006) and in cardiometabolic risk score beta in boys (0.8%, p = 0.030) but not in girls (0.5%, p = 0.051). Conclusions: Pubertal stage has an interaction effect on the association of cardiometabolic risk by BMI in boys and may have a similar but lesser effect in girls.-
dc.languageeng-
dc.publisherBiomedCentral. The Journal's web site is located at http://www.biomedcentral.com/bmcpediatr/-
dc.relation.ispartofBMC Pediatrics-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAssociations of pubertal stage and body mass index with cardiometabolic risk in Hong Kong Chinese children: A cross-sectional study-
dc.typeArticle-
dc.identifier.emailChan, PT: nptchan@hku.hk-
dc.identifier.authorityChan, PT=rp01680-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12887-015-0446-0-
dc.identifier.hkuros259824-
dc.identifier.volume15-
dc.identifier.spagearticle no. 136-
dc.identifier.epagearticle no. 136-

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