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Conference Paper: Periodontitis links with EPC counts in patients with T2 diabetes
Title | Periodontitis links with EPC counts in patients with T2 diabetes |
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Authors | |
Issue Date | 2016 |
Publisher | Sage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/ |
Citation | The 94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region & 35th Annual Meeting of the IADR Korean Division, Seoul, Korea, 22-25 June 2016. In Journal of Dental Research, 2016, v. 95 Spec. Iss. B, abstract no. 587 How to Cite? |
Abstract | OBJECTIVES: Periodontitis is closely associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. This study investigated the relationship of periodontitis with circulating endothelial progenitor cells (EPCs) in type 2 DM patients. METHODS: 26 subjects with chronic periodontitis and DM who had no history of coronary artery disease were recruited. All participants underwent full-month periodontal examination and venous blood was collected for flow cytometry and EPC culture. Four subpopulations of EPCs, including CD34+, CD133+, CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR + EPCs, were measured by flow cytometry; while monocytic EPCs were enumerated by immunohistochemistry in cultured peripheral blood mononuclear cells. RESULTS: A significant association between sites% with probing depth (PD) ≥5 mm and flow cytometry counts of EPCs was found (CD34+ cells: r=0.493, p=0.011; CD34+/KDR+ cells: r=0.390, p=0.049). Whereas, no significant correlation existed between PD and cultured monocytic EPCs. Further multivariate analysis indicated that only sites% with PD≥5 mm correlated with CD34+ cells (r=0.453, p=0.030) after adjusting for age, gender, BMI, smoking, hypertension, hypercholesterolemia, h1bAc and hs-CRP. CONCLUSIONS: This preliminary study suggests that chronic periodontitis could be associated with circulating CD34+ EPC counts in type 2 diabetes patients. Further study on functional activities of EPCs is warranted. |
Description | Poster Session - Systemic Conditions & Periodontal Disease Epidemiology II: no. 587 |
Persistent Identifier | http://hdl.handle.net/10722/227496 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.909 |
DC Field | Value | Language |
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dc.contributor.author | Wang, Y | - |
dc.contributor.author | Liu, HHL | - |
dc.contributor.author | Zhen, Z | - |
dc.contributor.author | Yiu, KH | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Pelekos, G | - |
dc.contributor.author | Jin, L | - |
dc.date.accessioned | 2016-07-18T09:11:03Z | - |
dc.date.available | 2016-07-18T09:11:03Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | The 94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region & 35th Annual Meeting of the IADR Korean Division, Seoul, Korea, 22-25 June 2016. In Journal of Dental Research, 2016, v. 95 Spec. Iss. B, abstract no. 587 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/227496 | - |
dc.description | Poster Session - Systemic Conditions & Periodontal Disease Epidemiology II: no. 587 | - |
dc.description.abstract | OBJECTIVES: Periodontitis is closely associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. This study investigated the relationship of periodontitis with circulating endothelial progenitor cells (EPCs) in type 2 DM patients. METHODS: 26 subjects with chronic periodontitis and DM who had no history of coronary artery disease were recruited. All participants underwent full-month periodontal examination and venous blood was collected for flow cytometry and EPC culture. Four subpopulations of EPCs, including CD34+, CD133+, CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR + EPCs, were measured by flow cytometry; while monocytic EPCs were enumerated by immunohistochemistry in cultured peripheral blood mononuclear cells. RESULTS: A significant association between sites% with probing depth (PD) ≥5 mm and flow cytometry counts of EPCs was found (CD34+ cells: r=0.493, p=0.011; CD34+/KDR+ cells: r=0.390, p=0.049). Whereas, no significant correlation existed between PD and cultured monocytic EPCs. Further multivariate analysis indicated that only sites% with PD≥5 mm correlated with CD34+ cells (r=0.453, p=0.030) after adjusting for age, gender, BMI, smoking, hypertension, hypercholesterolemia, h1bAc and hs-CRP. CONCLUSIONS: This preliminary study suggests that chronic periodontitis could be associated with circulating CD34+ EPC counts in type 2 diabetes patients. Further study on functional activities of EPCs is warranted. | - |
dc.language | eng | - |
dc.publisher | Sage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/ | - |
dc.relation.ispartof | Journal of Dental Research | - |
dc.rights | Journal of Dental Research. Copyright © Sage Publications, Inc. | - |
dc.title | Periodontitis links with EPC counts in patients with T2 diabetes | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Zhen, Z: zhenzhe@hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Pelekos, G: george74@hku.hk | - |
dc.identifier.email | Jin, L: ljjin@hkucc.hku.hk | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Pelekos, G=rp01894 | - |
dc.identifier.authority | Jin, L=rp00028 | - |
dc.identifier.hkuros | 259726 | - |
dc.identifier.volume | 95 | - |
dc.identifier.issue | Spec. Iss. B | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-0345 | - |