File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL

Conference Paper: Periodontitis links with EPC counts in patients with T2 diabetes

TitlePeriodontitis links with EPC counts in patients with T2 diabetes
Authors
Issue Date2016
PublisherSage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/
Citation
The 94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region & 35th Annual Meeting of the IADR Korean Division, Seoul, Korea, 22-25 June 2016. In Journal of Dental Research, 2016, v. 95 Spec. Iss. B, abstract no. 587 How to Cite?
AbstractOBJECTIVES: Periodontitis is closely associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. This study investigated the relationship of periodontitis with circulating endothelial progenitor cells (EPCs) in type 2 DM patients. METHODS: 26 subjects with chronic periodontitis and DM who had no history of coronary artery disease were recruited. All participants underwent full-month periodontal examination and venous blood was collected for flow cytometry and EPC culture. Four subpopulations of EPCs, including CD34+, CD133+, CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR + EPCs, were measured by flow cytometry; while monocytic EPCs were enumerated by immunohistochemistry in cultured peripheral blood mononuclear cells. RESULTS: A significant association between sites% with probing depth (PD) ≥5 mm and flow cytometry counts of EPCs was found (CD34+ cells: r=0.493, p=0.011; CD34+/KDR+ cells: r=0.390, p=0.049). Whereas, no significant correlation existed between PD and cultured monocytic EPCs. Further multivariate analysis indicated that only sites% with PD≥5 mm correlated with CD34+ cells (r=0.453, p=0.030) after adjusting for age, gender, BMI, smoking, hypertension, hypercholesterolemia, h1bAc and hs-CRP. CONCLUSIONS: This preliminary study suggests that chronic periodontitis could be associated with circulating CD34+ EPC counts in type 2 diabetes patients. Further study on functional activities of EPCs is warranted.
DescriptionPoster Session - Systemic Conditions & Periodontal Disease Epidemiology II: no. 587
Persistent Identifierhttp://hdl.handle.net/10722/227496
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorLiu, HHL-
dc.contributor.authorZhen, Z-
dc.contributor.authorYiu, KH-
dc.contributor.authorTse, HF-
dc.contributor.authorPelekos, G-
dc.contributor.authorJin, L-
dc.date.accessioned2016-07-18T09:11:03Z-
dc.date.available2016-07-18T09:11:03Z-
dc.date.issued2016-
dc.identifier.citationThe 94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region & 35th Annual Meeting of the IADR Korean Division, Seoul, Korea, 22-25 June 2016. In Journal of Dental Research, 2016, v. 95 Spec. Iss. B, abstract no. 587-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/227496-
dc.descriptionPoster Session - Systemic Conditions & Periodontal Disease Epidemiology II: no. 587-
dc.description.abstractOBJECTIVES: Periodontitis is closely associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. This study investigated the relationship of periodontitis with circulating endothelial progenitor cells (EPCs) in type 2 DM patients. METHODS: 26 subjects with chronic periodontitis and DM who had no history of coronary artery disease were recruited. All participants underwent full-month periodontal examination and venous blood was collected for flow cytometry and EPC culture. Four subpopulations of EPCs, including CD34+, CD133+, CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR + EPCs, were measured by flow cytometry; while monocytic EPCs were enumerated by immunohistochemistry in cultured peripheral blood mononuclear cells. RESULTS: A significant association between sites% with probing depth (PD) ≥5 mm and flow cytometry counts of EPCs was found (CD34+ cells: r=0.493, p=0.011; CD34+/KDR+ cells: r=0.390, p=0.049). Whereas, no significant correlation existed between PD and cultured monocytic EPCs. Further multivariate analysis indicated that only sites% with PD≥5 mm correlated with CD34+ cells (r=0.453, p=0.030) after adjusting for age, gender, BMI, smoking, hypertension, hypercholesterolemia, h1bAc and hs-CRP. CONCLUSIONS: This preliminary study suggests that chronic periodontitis could be associated with circulating CD34+ EPC counts in type 2 diabetes patients. Further study on functional activities of EPCs is warranted.-
dc.languageeng-
dc.publisherSage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/-
dc.relation.ispartofJournal of Dental Research-
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc.-
dc.titlePeriodontitis links with EPC counts in patients with T2 diabetes-
dc.typeConference_Paper-
dc.identifier.emailZhen, Z: zhenzhe@hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.hkuros259726-
dc.identifier.volume95-
dc.identifier.issueSpec. Iss. B-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats