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Article: Highly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N-vinyl-2-pyrrolidone)-Capped Platinum Nanoparticles

TitleHighly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N-vinyl-2-pyrrolidone)-Capped Platinum Nanoparticles
Authors
Keywordsbioelectronics
enzymatic biosensor
organic electrochemical transistor
Issue Date2016
PublisherJohn Wiley & Sons. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2365-709X
Citation
Advanced Materials Technologies, 2016, v. 1 n. 5, article no. 1600042 How to Cite?
AbstractOrganic electrochemical transistors (OECTs) are used as highly sensitive glucose and lactate sensors by modifying the gate electrode with glucose oxidase/lactate oxidase and poly(n-vinyl-2-pyrrolidone)-capped platinum nanoparticles (Pt NPs). The Pt NPs are deposited by using a two-step dip coating method without bias instead of the conventional electrodeposition method and followed by an UV-Ozone post treatment to enhance the catalytic ability of the Pt NPs. The modified OECT sensors have extremely high sensitivity, and can achieve a detection limit of glucose and lactate down to 10−7 and 10−6m, respectively. A polydimethylsiloxane microfluidic channel is successfully integrated with the OECT sensors, which provides a compact chip size of the sensors, a short detection time of around 1 min and extremely low consumption of analyte (30 (Formula presented.) L). The cross talk between individual sensors in multianalyte sensing devices is also reduced by the dual microfluidic channel structure. Practical applications, such as for detecting glucose in saliva, can therefore be realized, and a prototype of a portable glucose sensor has been successfully created in this study. This portable glucose sensor has excellent potential for real-time and noninvasive glucose sensing applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent Identifierhttp://hdl.handle.net/10722/227335
ISSN
2019 Impact Factor: 5.969
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJI, X-
dc.contributor.authorLau, HY-
dc.contributor.authorREN, X-
dc.contributor.authorPENG, B-
dc.contributor.authorZHAI, P-
dc.contributor.authorFeng, SP-
dc.contributor.authorChan, PKL-
dc.date.accessioned2016-07-18T09:09:51Z-
dc.date.available2016-07-18T09:09:51Z-
dc.date.issued2016-
dc.identifier.citationAdvanced Materials Technologies, 2016, v. 1 n. 5, article no. 1600042-
dc.identifier.issn2365-709X-
dc.identifier.urihttp://hdl.handle.net/10722/227335-
dc.description.abstractOrganic electrochemical transistors (OECTs) are used as highly sensitive glucose and lactate sensors by modifying the gate electrode with glucose oxidase/lactate oxidase and poly(n-vinyl-2-pyrrolidone)-capped platinum nanoparticles (Pt NPs). The Pt NPs are deposited by using a two-step dip coating method without bias instead of the conventional electrodeposition method and followed by an UV-Ozone post treatment to enhance the catalytic ability of the Pt NPs. The modified OECT sensors have extremely high sensitivity, and can achieve a detection limit of glucose and lactate down to 10−7 and 10−6m, respectively. A polydimethylsiloxane microfluidic channel is successfully integrated with the OECT sensors, which provides a compact chip size of the sensors, a short detection time of around 1 min and extremely low consumption of analyte (30 (Formula presented.) L). The cross talk between individual sensors in multianalyte sensing devices is also reduced by the dual microfluidic channel structure. Practical applications, such as for detecting glucose in saliva, can therefore be realized, and a prototype of a portable glucose sensor has been successfully created in this study. This portable glucose sensor has excellent potential for real-time and noninvasive glucose sensing applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.languageeng-
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2365-709X-
dc.relation.ispartofAdvanced Materials Technologies-
dc.rightsThis is the peer reviewed version of the following article: Advanced Materials Technologies, 2016, v. 1 n. 5, article no. 1600042, which has been published in final form at https://doi.org/10.1002/admt.201600042. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbioelectronics-
dc.subjectenzymatic biosensor-
dc.subjectorganic electrochemical transistor-
dc.titleHighly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N-vinyl-2-pyrrolidone)-Capped Platinum Nanoparticles-
dc.typeArticle-
dc.identifier.emailLau, HY: albertra@hku.hk-
dc.identifier.emailFeng, S-P: hpfeng@hku.hk-
dc.identifier.emailChan, PKL: pklc@hku.hk-
dc.identifier.authorityFeng, S-P=rp01533-
dc.identifier.authorityChan, PKL=rp01532-
dc.description.naturepostprint-
dc.identifier.doi10.1002/admt.201600042-
dc.identifier.scopuseid_2-s2.0-85038387850-
dc.identifier.hkuros258967-
dc.identifier.hkuros308562-
dc.identifier.volume1-
dc.identifier.issue5-
dc.identifier.spagearticle no. 1600042-
dc.identifier.epagearticle no. 1600042-
dc.identifier.isiWOS:000398995800001-
dc.publisher.placeHong Kong-

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