File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B

TitleMiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B
Authors
Issue Date2016
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2016, v. 11 n. 1, p. e0146770 How to Cite?
AbstractMicroRNAs are emerging post-transcriptional regulators of gene expressions in both innate immunity and adaptive immunity. In mycobacteria infection, autophagy plays an important role in innate defense mechanism and is tightly regulated by the autophagy-related proteins. Here, we show that Atg2B is involved in the regulation of mycobacteria-induced autophagy. MiR-1303, which function is not defined yet, is found to negatively regulate mycobacteria-induced Atg2B protein production, ultimately down-regulate mycobacteria-induced autophagy. MiR-1303 production is shown to be upregulated during BCG infection and its production is regulated by PI3K and NFκB. It is also demonstrated that miR-1303 targets putative target sites on Atg2B and possibly represses its translation.
Persistent Identifierhttp://hdl.handle.net/10722/227009
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAu, KY-
dc.contributor.authorPong, JCH-
dc.contributor.authorLing, WL-
dc.contributor.authorLi, CB-
dc.date.accessioned2016-07-14T04:27:11Z-
dc.date.available2016-07-14T04:27:11Z-
dc.date.issued2016-
dc.identifier.citationPLoS One, 2016, v. 11 n. 1, p. e0146770-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/227009-
dc.description.abstractMicroRNAs are emerging post-transcriptional regulators of gene expressions in both innate immunity and adaptive immunity. In mycobacteria infection, autophagy plays an important role in innate defense mechanism and is tightly regulated by the autophagy-related proteins. Here, we show that Atg2B is involved in the regulation of mycobacteria-induced autophagy. MiR-1303, which function is not defined yet, is found to negatively regulate mycobacteria-induced Atg2B protein production, ultimately down-regulate mycobacteria-induced autophagy. MiR-1303 production is shown to be upregulated during BCG infection and its production is regulated by PI3K and NFκB. It is also demonstrated that miR-1303 targets putative target sites on Atg2B and possibly represses its translation.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B-
dc.typeArticle-
dc.identifier.emailLi, CB: jamesli@graduate.hku.hk-
dc.identifier.authorityLi, CB=rp00496-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0146770-
dc.identifier.pmid26771516-
dc.identifier.hkuros269707-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spagee0146770-
dc.identifier.epagee0146770-
dc.identifier.isiWOS:000368628300034-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats