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Article: Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI

TitleSerum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI
Authors
Issue Date2015
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLOS One, 2015, v. 10 n. 7, p. e0133362 How to Cite?
AbstractThe TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis. To further characterize the role of MIC-1/GDF15 in physiological regulation of energy homeostasis in man, we have examined diurnal and food associated variation in serum levels and whether variation in circulating levels relate to BMI in human monozygotic twin pairs. We found that the within twin pair differences in serum MIC-1/GDF15 levels were significantly correlated with within twin pair differences in BMI, suggesting a role for MIC-1/GDF15 in the regulation of energy balance in man. MIC-1/GDF15 serum levels altered slightly in response to a meal, but comparison with variation its serum levels over a 24hour period suggested that these changes are likely to be due to bimodal diurnal variation which can alter serum MIC-1/GDF15 levels by about plus or minus 10% from the mesor. The lack of a rapid and substantial postprandial increase in MIC-1/GDF15 serum levels suggests that MIC1/GDF15 is unlikely to act as a satiety factor. Taken together, our findings suggest that MIC-1/GDF15 may be a physiological regulator of energy homeostasis in man, most probably due to actions on long-term regulation of energy homeostasis.
Persistent Identifierhttp://hdl.handle.net/10722/226671
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsai, VW-
dc.contributor.authorMacia, L-
dc.contributor.authorFeinle-Bisset, C-
dc.contributor.authorManandhar, R-
dc.contributor.authorAstrup, A-
dc.contributor.authorRaben, A-
dc.contributor.authorLorenzen, JK-
dc.contributor.authorSchmidt, PT-
dc.contributor.authorWiklund, F-
dc.contributor.authorPedersen, NL-
dc.contributor.authorCampbell, L-
dc.contributor.authorKriketos, A-
dc.contributor.authorXu, A-
dc.contributor.authorZhou, P-
dc.contributor.authorJia, W-
dc.contributor.authorCurmi, PMG-
dc.contributor.authorAngstmann, CN-
dc.contributor.authorLee-Ng, KKM-
dc.contributor.authorZhang, HP-
dc.contributor.authorMarquis, CP-
dc.contributor.authorHusaini, Y-
dc.contributor.authorBeglinger, C-
dc.contributor.authorLin, S-
dc.contributor.authorHerzog, H-
dc.contributor.authorBrown, DA-
dc.contributor.authorSainsbury, A-
dc.contributor.authorBreit, SN-
dc.date.accessioned2016-06-24T01:27:49Z-
dc.date.available2016-06-24T01:27:49Z-
dc.date.issued2015-
dc.identifier.citationPLOS One, 2015, v. 10 n. 7, p. e0133362-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/226671-
dc.description.abstractThe TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis. To further characterize the role of MIC-1/GDF15 in physiological regulation of energy homeostasis in man, we have examined diurnal and food associated variation in serum levels and whether variation in circulating levels relate to BMI in human monozygotic twin pairs. We found that the within twin pair differences in serum MIC-1/GDF15 levels were significantly correlated with within twin pair differences in BMI, suggesting a role for MIC-1/GDF15 in the regulation of energy balance in man. MIC-1/GDF15 serum levels altered slightly in response to a meal, but comparison with variation its serum levels over a 24hour period suggested that these changes are likely to be due to bimodal diurnal variation which can alter serum MIC-1/GDF15 levels by about plus or minus 10% from the mesor. The lack of a rapid and substantial postprandial increase in MIC-1/GDF15 serum levels suggests that MIC1/GDF15 is unlikely to act as a satiety factor. Taken together, our findings suggest that MIC-1/GDF15 may be a physiological regulator of energy homeostasis in man, most probably due to actions on long-term regulation of energy homeostasis.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLOS One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSerum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI-
dc.typeArticle-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0133362-
dc.identifier.pmid26207898-
dc.identifier.pmcidPMC4514813-
dc.identifier.volume10-
dc.identifier.issue7-
dc.identifier.spagee0133362-
dc.identifier.epagee0133362-
dc.identifier.isiWOS:000358622000082-
dc.publisher.placeUnited States-

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