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Article: Hospital-based vaccine effectiveness against influenza B lineages, Hong Kong, 2009−14

TitleHospital-based vaccine effectiveness against influenza B lineages, Hong Kong, 2009−14
Authors
Issue Date2016
Citation
Vaccine, 2016, v. 34 n. 19, p. 2164-2169 How to Cite?
AbstractBACKGROUND: We estimated vaccine effectiveness (VE) against pediatric influenza B hospitalizations in Hong Kong year round between November 2001 and October 2014. METHODS: We conducted a test-negative year-round study, enrolling children 6 months to 17 years of age admitted to two hospitals in Hong Kong with a febrile acute respiratory infection. Children were tested for influenza A and B. Conditional logistic regression was used to estimate overall and lineage-specific vaccine effectiveness comparing influenza vaccination history of the trivalent influenza vaccine (TIV) among patients testing positive for influenza B versus negative for influenza A and B, adjusting for age and sex and matching by calendar week of recruitment. RESULTS: Of the 6013 children included in the analysis, 262 tested positive for influenza B. Vaccination coverage was low: 6.5% in the influenza B positive children when compared with 8.8% in children who tested negative for both influenza A and B (p=0.248). Overall, VE was 47.6% (95% CI: 10.0, 69.4%) against influenza B hospitalization despite variable co-circulation of both lineages in all years. VE for Victoria-like virus calculated from 3 years when the vaccine was lineage-matched was 59.1% (95% CI: 6.2, 82.2%). Lineage-matched VE for Yamagata-like virus was -8.8% (95% CI: -215.4, 62.5%) in a clade mismatch season. With wide confidence intervals, we were unable to demonstrate cross-lineage protection: VE against the mismatched B/Yamagata-like virus was 9.5% (95% CI: -240.4, 76.0%) in 2011/12 and against mismatched B/Victoria-like virus in 2013/14 was 42.7% (95% CI: -368.6, 93.0%). CONCLUSIONS: TIV conferred an overall VE of 47.6% (95% CI: 10.0, 69.4%) against influenza B hospitalization in children despite variable co-circulation of both lineages in all years. Lineage-matched VE for Yamagata-like virus was poor and may be related to clade mismatch. Cross-lineage protection was not observed.
Persistent Identifierhttp://hdl.handle.net/10722/226633

 

DC FieldValueLanguage
dc.contributor.authorChiu, SSS-
dc.contributor.authorNicholls, JM-
dc.contributor.authorChan, KH-
dc.contributor.authorLo, JY-
dc.contributor.authorChan, LY-
dc.contributor.authorSo, LY-
dc.contributor.authorCowling, BJ-
dc.contributor.authorPeiris, JSM-
dc.date.accessioned2016-06-17T07:45:20Z-
dc.date.available2016-06-17T07:45:20Z-
dc.date.issued2016-
dc.identifier.citationVaccine, 2016, v. 34 n. 19, p. 2164-2169-
dc.identifier.urihttp://hdl.handle.net/10722/226633-
dc.description.abstractBACKGROUND: We estimated vaccine effectiveness (VE) against pediatric influenza B hospitalizations in Hong Kong year round between November 2001 and October 2014. METHODS: We conducted a test-negative year-round study, enrolling children 6 months to 17 years of age admitted to two hospitals in Hong Kong with a febrile acute respiratory infection. Children were tested for influenza A and B. Conditional logistic regression was used to estimate overall and lineage-specific vaccine effectiveness comparing influenza vaccination history of the trivalent influenza vaccine (TIV) among patients testing positive for influenza B versus negative for influenza A and B, adjusting for age and sex and matching by calendar week of recruitment. RESULTS: Of the 6013 children included in the analysis, 262 tested positive for influenza B. Vaccination coverage was low: 6.5% in the influenza B positive children when compared with 8.8% in children who tested negative for both influenza A and B (p=0.248). Overall, VE was 47.6% (95% CI: 10.0, 69.4%) against influenza B hospitalization despite variable co-circulation of both lineages in all years. VE for Victoria-like virus calculated from 3 years when the vaccine was lineage-matched was 59.1% (95% CI: 6.2, 82.2%). Lineage-matched VE for Yamagata-like virus was -8.8% (95% CI: -215.4, 62.5%) in a clade mismatch season. With wide confidence intervals, we were unable to demonstrate cross-lineage protection: VE against the mismatched B/Yamagata-like virus was 9.5% (95% CI: -240.4, 76.0%) in 2011/12 and against mismatched B/Victoria-like virus in 2013/14 was 42.7% (95% CI: -368.6, 93.0%). CONCLUSIONS: TIV conferred an overall VE of 47.6% (95% CI: 10.0, 69.4%) against influenza B hospitalization in children despite variable co-circulation of both lineages in all years. Lineage-matched VE for Yamagata-like virus was poor and may be related to clade mismatch. Cross-lineage protection was not observed.-
dc.languageeng-
dc.relation.ispartofVaccine-
dc.titleHospital-based vaccine effectiveness against influenza B lineages, Hong Kong, 2009−14-
dc.typeArticle-
dc.identifier.emailChiu, SSS: ssschiu@hku.hk-
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailChan, LY: laiyin@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityChiu, SSS=rp00421-
dc.identifier.authorityNicholls, JM=rp00364-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.doi10.1016/j.vaccine.2016.03.032-
dc.identifier.hkuros258354-
dc.identifier.volume34-
dc.identifier.issue19-
dc.identifier.spage2164-
dc.identifier.epage2169-

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