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Article: Prenatal Tobacco Exposure Shortens Telomere Length in Children

TitlePrenatal Tobacco Exposure Shortens Telomere Length in Children
Authors
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://ntr.oxfordjournals.org/
Citation
Nicotine & Tobacco Research, 2017, v. 19 n. 1, p. 111-118 How to Cite?
AbstractIntroduction: Preliminary evidence suggests a possible association between prenatal tobacco exposure and telomere length in children. This study was conducted to investigate whether maternal smoking during pregnancy was associated with telomere shortening in their children and whether prenatal and childhood exposure to environmental tobacco had any impact on this association. Methods: This is a population-representative study on the association between prenatal tobacco exposure and telomere length in children. Ninety-eight Hong Kong Chinese children aged under 15 years with prenatal tobacco exposure and 98 age- and gender-matched controls were recruited from a population health study with stratified random sampling. Results: Telomere length in children with prenatal tobacco exposure was significantly shorter than in those with no exposure (mean T/S ratio = 24.9 [SD = 8.58] in exposed vs. 28.97 [14.15] in control groups; P = 0.02). A negative dose-response relationship was observed between the T/S ratio and tobacco exposure duration: the longer the duration of maternal smoking in pregnancy, the shorter the child's telomere length. The association between the child's telomere length and prenatal tobacco exposure remained significant after considering the influence of family socioeconomic status and exposure to environmental tobacco smoke during pregnancy and childhood. Conclusions: Prenatal tobacco exposure was associated with telomere shortening in children. As this may impose significant health impacts through fetal genetic programming, more efforts should be made to reduce fetal tobacco exposure by educating pregnant women to not smoke and motivating smokers to quit in early pregnancy. Implications: As reflected by telomere shortening, prenatal tobacco exposure in children can cause premature aging and increased health risks, which we suggest is entirely preventable. Not smoking during pregnancy or quitting smoking is critical to improving the health outcome of our future generations as prenatal tobacco exposure may affect children's biological programming. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/226373
ISSN
2015 Impact Factor: 3.811
2015 SCImago Journal Rankings: 1.904

 

DC FieldValueLanguage
dc.contributor.authorIp, P-
dc.contributor.authorChung, BHY-
dc.contributor.authorHo, FKW-
dc.contributor.authorChan, GCF-
dc.contributor.authorDeng, W-
dc.contributor.authorWong, WHS-
dc.contributor.authorLee, SL-
dc.contributor.authorChan, PYT-
dc.contributor.authorYing, D-
dc.contributor.authorWong, WL-
dc.contributor.authorTung, TS-
dc.contributor.authorLau, YL-
dc.date.accessioned2016-06-17T07:43:42Z-
dc.date.available2016-06-17T07:43:42Z-
dc.date.issued2017-
dc.identifier.citationNicotine & Tobacco Research, 2017, v. 19 n. 1, p. 111-118-
dc.identifier.issn1462-2203-
dc.identifier.urihttp://hdl.handle.net/10722/226373-
dc.description.abstractIntroduction: Preliminary evidence suggests a possible association between prenatal tobacco exposure and telomere length in children. This study was conducted to investigate whether maternal smoking during pregnancy was associated with telomere shortening in their children and whether prenatal and childhood exposure to environmental tobacco had any impact on this association. Methods: This is a population-representative study on the association between prenatal tobacco exposure and telomere length in children. Ninety-eight Hong Kong Chinese children aged under 15 years with prenatal tobacco exposure and 98 age- and gender-matched controls were recruited from a population health study with stratified random sampling. Results: Telomere length in children with prenatal tobacco exposure was significantly shorter than in those with no exposure (mean T/S ratio = 24.9 [SD = 8.58] in exposed vs. 28.97 [14.15] in control groups; P = 0.02). A negative dose-response relationship was observed between the T/S ratio and tobacco exposure duration: the longer the duration of maternal smoking in pregnancy, the shorter the child's telomere length. The association between the child's telomere length and prenatal tobacco exposure remained significant after considering the influence of family socioeconomic status and exposure to environmental tobacco smoke during pregnancy and childhood. Conclusions: Prenatal tobacco exposure was associated with telomere shortening in children. As this may impose significant health impacts through fetal genetic programming, more efforts should be made to reduce fetal tobacco exposure by educating pregnant women to not smoke and motivating smokers to quit in early pregnancy. Implications: As reflected by telomere shortening, prenatal tobacco exposure in children can cause premature aging and increased health risks, which we suggest is entirely preventable. Not smoking during pregnancy or quitting smoking is critical to improving the health outcome of our future generations as prenatal tobacco exposure may affect children's biological programming. © The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ntr.oxfordjournals.org/-
dc.relation.ispartofNicotine & Tobacco Research-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nicotine & Tobacco Research following peer review. The definitive publisher-authenticated version Nicotine & Tobacco Research, 2017, v. 19 n. 1, p. 111-118 is available online at: https://academic.oup.com/ntr/article-abstract/19/1/111/2698742/Prenatal-Tobacco-Exposure-Shortens-Telomere-Length?redirectedFrom=fulltext-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePrenatal Tobacco Exposure Shortens Telomere Length in Children-
dc.typeArticle-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailChung, BHY: bhychung@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hk-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailLee, SL: slleem@hku.hk-
dc.identifier.emailYing, D: jonson@hku.hk-
dc.identifier.emailWong, WL: wlapwong@hku.hk-
dc.identifier.emailTung, TS: ktung@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityChung, BHY=rp00473-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityDeng, W=rp01640-
dc.identifier.authorityLau, YL=rp00361-
dc.description.naturepostprint-
dc.identifier.doi10.1093/ntr/ntw139-
dc.identifier.hkuros258692-
dc.identifier.volume19-
dc.identifier.issue1-
dc.identifier.spage111-
dc.identifier.epage118-
dc.publisher.placeUnited Kingdom-

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