File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions

TitleThe spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions
Authors
KeywordsMesoporous silica nanoparticles
Morphology
Chlorhexidine
Imaging
Biofilms
Issue Date2016
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5
Citation
International Journal of Nanomedicine, 2016, v. 11, p. 2471 How to Cite?
AbstractWe reported two forms (sphere and wire) of newly fabricated chlorhexidine (CHX)-loaded mesoporous silica nanoparticles (MSNs), and investigated their releasing capacities and anti-biofilm efficiencies. The interactions of the blank MSNs with planktonic oral microorganisms were assessed by field emission scanning electron microscopy. The anti-biofilm effects of the two forms of nanoparticle-encapsulated CHX were examined by 2,3-bis (2-methoxy- 4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide. The profiles of biofilm penetration were analyzed by fluorescent-labeled MSNs using confocal microscopy and ImageJ. The spherical MSNs with an average diameter of 265 nm exhibited a larger surface area and faster CHX-releasing rate than the MSN wires. The field emission scanning electron microscopy images showed that both shaped MSNs enabled to attach and further fuse with the surfaces of testing microbes. Meanwhile, the nanoparticle-encapsulated CHX could enhance the anti-biofilm efficiency with reference to its free form. Notably, the spherical nanoparticle-encapsulated CHX presented with a greater anti-biofilm capacity than the wire nanoparticle-encapsulated CHX, partly due to their difference in physical property. Furthermore, the relatively even distribution and homogeneous dispersion of spherical MSNs observed in confocal images may account for the enhanced penetration of spherical nanoparticle-encapsulated CHX into the microbial biofilms and resultant anti-biofilm effects. These findings reveal that the spherical nanoparticle-encapsulated CHX could preferably enhance its anti-biofilm efficiency through an effective releasing mode and close interactions with microbes.
Persistent Identifierhttp://hdl.handle.net/10722/226296
ISSN
2010 Impact Factor: 4.976
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLI, X-
dc.contributor.authorWong, CH-
dc.contributor.authorNg, TW-
dc.contributor.authorZhang, C-
dc.contributor.authorLeung, KCF-
dc.contributor.authorJin, L-
dc.date.accessioned2016-06-17T07:43:07Z-
dc.date.available2016-06-17T07:43:07Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Nanomedicine, 2016, v. 11, p. 2471-
dc.identifier.issn1176-9114-
dc.identifier.urihttp://hdl.handle.net/10722/226296-
dc.description.abstractWe reported two forms (sphere and wire) of newly fabricated chlorhexidine (CHX)-loaded mesoporous silica nanoparticles (MSNs), and investigated their releasing capacities and anti-biofilm efficiencies. The interactions of the blank MSNs with planktonic oral microorganisms were assessed by field emission scanning electron microscopy. The anti-biofilm effects of the two forms of nanoparticle-encapsulated CHX were examined by 2,3-bis (2-methoxy- 4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide. The profiles of biofilm penetration were analyzed by fluorescent-labeled MSNs using confocal microscopy and ImageJ. The spherical MSNs with an average diameter of 265 nm exhibited a larger surface area and faster CHX-releasing rate than the MSN wires. The field emission scanning electron microscopy images showed that both shaped MSNs enabled to attach and further fuse with the surfaces of testing microbes. Meanwhile, the nanoparticle-encapsulated CHX could enhance the anti-biofilm efficiency with reference to its free form. Notably, the spherical nanoparticle-encapsulated CHX presented with a greater anti-biofilm capacity than the wire nanoparticle-encapsulated CHX, partly due to their difference in physical property. Furthermore, the relatively even distribution and homogeneous dispersion of spherical MSNs observed in confocal images may account for the enhanced penetration of spherical nanoparticle-encapsulated CHX into the microbial biofilms and resultant anti-biofilm effects. These findings reveal that the spherical nanoparticle-encapsulated CHX could preferably enhance its anti-biofilm efficiency through an effective releasing mode and close interactions with microbes.-
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5-
dc.relation.ispartofInternational Journal of Nanomedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMesoporous silica nanoparticles-
dc.subjectMorphology-
dc.subjectChlorhexidine-
dc.subjectImaging-
dc.subjectBiofilms-
dc.titleThe spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions-
dc.typeArticle-
dc.identifier.emailZhang, C: zhangcf@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityZhang, C=rp01408-
dc.identifier.authorityJin, L=rp00028-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/IJN.S105681-
dc.identifier.scopuseid_2-s2.0-84971515781-
dc.identifier.hkuros258391-
dc.identifier.volume11-
dc.identifier.spage2471-
dc.identifier.epage2471-
dc.identifier.isiWOS:000377085500001-
dc.publisher.placeNew Zealand-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats