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Article: Cord blood IgE: its determinants and prediction of development of asthma and other allergic disorders at 12 months

TitleCord blood IgE: its determinants and prediction of development of asthma and other allergic disorders at 12 months
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.annallergy.org
Citation
Annals of Allergy, Asthma & Immunology, 2000, v. 84 n. 1, p. 37-42 How to Cite?
AbstractBACKGROUND: The value of cord blood IgE in predicting the development of asthma and other IgE-mediated allergic diseases is unclear. OBJECTIVE: The purpose of this study is twofold: (1) to determine factors affecting cord blood IgE level and (2) to determine whether cord blood IgE predicts the development of asthma and other IgE-mediated allergic diseases in high risk (defined as those with at least one first degree relative with asthma or 2 first degree relatives with other IgE-mediated allergic diseases) infants at 12 months. METHODS: The study utilized cord blood obtained from a group of high risk infants who took part in a randomized controlled trial to assess the effectiveness of an intervention program in the primary prevention of asthma and other IgE-mediated allergic diseases. Total IgE and cotinine in the cord blood were measured. Assessment of the infants was done at 12 months for these diseases. RESULTS: Sixty-four (17.8%) infants had detectable total IgE in cord blood >0.5 kU/L. The proportion of infants with elevated cord blood IgE was significantly higher among nonwhites, birth during winter months, and those with a maternal history of asthma. There was no correlation between cord blood IgE and cord blood cotinine level. Cord blood IgE was found to be a significant predictor for the development of urticaria due to food allergy but not for other outcomes. CONCLUSION: Both genetic and environmental risk factors play a role in determining the level of IgE in cord blood. Cord blood IgE was a significant risk factor for the development of urticaria due to food allergy at 12 months of life. As urticaria due to food allergy is a prodrome for anaphylaxis, measurement of IgE in cord blood may be indicated in infants at high risk for developing allergic diseases so that preventive measures can be applied.
Persistent Identifierhttp://hdl.handle.net/10722/225928
ISSN
2015 Impact Factor: 3.475
2015 SCImago Journal Rankings: 1.268

 

DC FieldValueLanguage
dc.contributor.authorKaan, A-
dc.contributor.authorDimich-Ward, H-
dc.contributor.authorManfreda, J-
dc.contributor.authorBecker, A-
dc.contributor.authorWatson, W-
dc.contributor.authorFerguson, A-
dc.contributor.authorChan, H-
dc.contributor.authorChan, MMW-
dc.date.accessioned2016-05-25T08:04:41Z-
dc.date.available2016-05-25T08:04:41Z-
dc.date.issued2000-
dc.identifier.citationAnnals of Allergy, Asthma & Immunology, 2000, v. 84 n. 1, p. 37-42-
dc.identifier.issn1081-1206-
dc.identifier.urihttp://hdl.handle.net/10722/225928-
dc.description.abstractBACKGROUND: The value of cord blood IgE in predicting the development of asthma and other IgE-mediated allergic diseases is unclear. OBJECTIVE: The purpose of this study is twofold: (1) to determine factors affecting cord blood IgE level and (2) to determine whether cord blood IgE predicts the development of asthma and other IgE-mediated allergic diseases in high risk (defined as those with at least one first degree relative with asthma or 2 first degree relatives with other IgE-mediated allergic diseases) infants at 12 months. METHODS: The study utilized cord blood obtained from a group of high risk infants who took part in a randomized controlled trial to assess the effectiveness of an intervention program in the primary prevention of asthma and other IgE-mediated allergic diseases. Total IgE and cotinine in the cord blood were measured. Assessment of the infants was done at 12 months for these diseases. RESULTS: Sixty-four (17.8%) infants had detectable total IgE in cord blood >0.5 kU/L. The proportion of infants with elevated cord blood IgE was significantly higher among nonwhites, birth during winter months, and those with a maternal history of asthma. There was no correlation between cord blood IgE and cord blood cotinine level. Cord blood IgE was found to be a significant predictor for the development of urticaria due to food allergy but not for other outcomes. CONCLUSION: Both genetic and environmental risk factors play a role in determining the level of IgE in cord blood. Cord blood IgE was a significant risk factor for the development of urticaria due to food allergy at 12 months of life. As urticaria due to food allergy is a prodrome for anaphylaxis, measurement of IgE in cord blood may be indicated in infants at high risk for developing allergic diseases so that preventive measures can be applied.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.annallergy.org-
dc.relation.ispartofAnnals of Allergy, Asthma & Immunology-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subject.meshAsthma - etiology-
dc.subject.meshFetal Blood - immunology-
dc.subject.meshHypersensitivity - etiology-
dc.subject.meshImmunoglobulin E - blood-
dc.subject.meshSmoking - adverse effects-
dc.titleCord blood IgE: its determinants and prediction of development of asthma and other allergic disorders at 12 months-
dc.typeArticle-
dc.identifier.emailChan, MMW: mmwchan@hku.hk-
dc.identifier.doi10.1016/S1081-1206(10)62738-X-
dc.identifier.pmid10674563-
dc.identifier.hkuros52603-
dc.identifier.volume84-
dc.identifier.issue1-
dc.identifier.spage37-
dc.identifier.epage42-
dc.publisher.placeUnited States-

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