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Article: Normal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy

TitleNormal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy
Authors
Issue Date2016
Citation
Nuclear Medicine Communications, 2016, p. 1 How to Cite?
AbstractAIM: Knowledge of the normal range of periprosthetic osteoblastic activity around total hip arthroplasties is required for rational diagnosis of complications. The aim of this study was to establish such a normal range for single-photon emission computed tomography (SPECT). Clinical utility of such a range is confident differentiation of normal from abnormal arthroplasties. METHODS: A total of 122 asymptomatic acetabular cups (age: 0-22 years) and 71 femoral stems (age: 0-20 years) were scanned with SPECT/CT. Two acetabular and three femoral activity ratios to normal reference bone were defined [acetabular axial (AA/RA), acetabular coronal (AC/RA), RA=reference acetabulum; femoral calcar (FC/RF), femoral mid-stem (FM/RF), femoral stem tip (FS/RF), RF=reference femur]. Upper cut-off of normal was defined as mean +3 SD (rounded). Two time breakpoints were analysed (12 and 24 months). RESULTS: The upper cut-off for the normal range was 1.0 for AA/RA, 1.5 for AC/RA and 2.2 for all thee of FC/RF, FM/RF and FS/RF. AA/RA, FM/RF and FS/RF showed no statistically significant temporal trends. AC/RA showed stabilization of activity after 12 months and FC/RF after 24 months. CONCLUSION: Measured activity ratios that fall within our normal range are likely to represent normal periprosthetic osteoblastic activity. Measured activity ratios that fall above the upper cut-offs of our normal range are likely to be abnormal. The cut-offs are robust in clinical practice and have utility in discriminating normal from abnormal stabilized arthroplasties where visual interpretation is ambiguous. Elevated AC/RA under 12 months and FC/RF under 24 months may represent normal periprosthetic activity and should be interpreted with caution.
Persistent Identifierhttp://hdl.handle.net/10722/225646

 

DC FieldValueLanguage
dc.contributor.authorJin, S-
dc.contributor.authorBoktor, RR-
dc.contributor.authorMan, KCK-
dc.contributor.authorPitman, AG-
dc.date.accessioned2016-05-20T08:09:43Z-
dc.date.available2016-05-20T08:09:43Z-
dc.date.issued2016-
dc.identifier.citationNuclear Medicine Communications, 2016, p. 1-
dc.identifier.urihttp://hdl.handle.net/10722/225646-
dc.description.abstractAIM: Knowledge of the normal range of periprosthetic osteoblastic activity around total hip arthroplasties is required for rational diagnosis of complications. The aim of this study was to establish such a normal range for single-photon emission computed tomography (SPECT). Clinical utility of such a range is confident differentiation of normal from abnormal arthroplasties. METHODS: A total of 122 asymptomatic acetabular cups (age: 0-22 years) and 71 femoral stems (age: 0-20 years) were scanned with SPECT/CT. Two acetabular and three femoral activity ratios to normal reference bone were defined [acetabular axial (AA/RA), acetabular coronal (AC/RA), RA=reference acetabulum; femoral calcar (FC/RF), femoral mid-stem (FM/RF), femoral stem tip (FS/RF), RF=reference femur]. Upper cut-off of normal was defined as mean +3 SD (rounded). Two time breakpoints were analysed (12 and 24 months). RESULTS: The upper cut-off for the normal range was 1.0 for AA/RA, 1.5 for AC/RA and 2.2 for all thee of FC/RF, FM/RF and FS/RF. AA/RA, FM/RF and FS/RF showed no statistically significant temporal trends. AC/RA showed stabilization of activity after 12 months and FC/RF after 24 months. CONCLUSION: Measured activity ratios that fall within our normal range are likely to represent normal periprosthetic osteoblastic activity. Measured activity ratios that fall above the upper cut-offs of our normal range are likely to be abnormal. The cut-offs are robust in clinical practice and have utility in discriminating normal from abnormal stabilized arthroplasties where visual interpretation is ambiguous. Elevated AC/RA under 12 months and FC/RF under 24 months may represent normal periprosthetic activity and should be interpreted with caution.-
dc.languageeng-
dc.relation.ispartofNuclear Medicine Communications-
dc.titleNormal range of osteoblastic activity in total hip arthroplasties on single-photon emission computed tomography bone scintigraphy-
dc.typeArticle-
dc.identifier.emailMan, KCK: mkckth@hku.hk-
dc.identifier.doi10.1097/MNM.0000000000000537-
dc.identifier.hkuros258106-
dc.identifier.spage1-
dc.identifier.epage1-

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