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Article: Effects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial

TitleEffects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial
Authors
KeywordsBody composition
Gestational diabetes mellitus
Glycemic index
Infant
Intima-media thickness
Issue Date2016
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/
Citation
American Journal of Clinical Nutrition, 2016, v. 103 n. 4, p. 1073-1082 How to Cite?
AbstractBACKGROUND: Elevated maternal blood glucose concentrations may contribute to macrosomia, adiposity, and poorer vascular health in the offspring. OBJECTIVE: The aim was to explore the effect of a low-glycemic index (low-GI) diet during pregnancy on offspring growth, adiposity, and arterial wall thickness during infancy. DESIGN: This was a longitudinal follow-up study in a self-selected subgroup of mother-infant pairs (n= 59) participating in a larger randomized trial comparing the effects on perinatal outcomes of a low-GI diet and a conventional high-fiber (HF) diet during pregnancy. Infant anthropometric measurements were taken every month for 6 mo and then at 9 and 12 mo of age. Adiposity was assessed at birth and at 3 mo by air-displacement plethysmography by using the Pea Pod system (Cosmed) and at 6 and 12 mo by bioimpedance analysis (Bodystat). Aortic intima-media thickness was assessed at 12 mo by high-resolution ultrasound (Philips). RESULTS: Maternal dietary GI was lower in the low-GI group than in the HF group (51 ± 1 compared with 57 ± 1;P< 0.001). No differences in neonatal outcomes were observed in the main trial. In the self-selected subsample, birth weight and lengthzscores were lower in the low-GI group than in the HF group (birth weightzscore: 0.2 ± 0.2 compared with 0.7 ± 0.2, respectively;P= 0.04; birth lengthzscore: 0.3 ± 0.2 compared with 0.9 ± 0.2, respectively;P= 0.04), but adiposity from birth to 12 mo of age and growth trajectories from 1 to 12 mo of age were similar. Aortic intima-media thickness was lower in the low-GI group than in the HF group (657 ±12 compared with 696 ± 12 μm, respectively;P= 0.02), which was partly mediated by differences in birth weight. CONCLUSION: In women at risk of gestational diabetes mellitus, a low-GI diet influences offspring birth weight, birth length, and arterial wall thickness in early childhood, but not adiposity or growth trajectory during the first year of life. This trial was registered atanzctr.orgau as ACTRN12610000681055.
Persistent Identifierhttp://hdl.handle.net/10722/225478
ISSN
2015 Impact Factor: 6.703
2015 SCImago Journal Rankings: 3.771

 

DC FieldValueLanguage
dc.contributor.authorKizirian, NV-
dc.contributor.authorKong, Y-
dc.contributor.authorMuirhead, R-
dc.contributor.authorBrodie, S-
dc.contributor.authorGarnett, SP-
dc.contributor.authorPetocz, P-
dc.contributor.authorSim, KA-
dc.contributor.authorCelermajer, DS-
dc.contributor.authorLouie, CYJ-
dc.contributor.authorMarkovic, TP-
dc.contributor.authorRoss, GP-
dc.contributor.authorWard, LC-
dc.contributor.authorBrand-Miller, JC-
dc.contributor.authorSkilton, MR-
dc.date.accessioned2016-05-18T01:21:41Z-
dc.date.available2016-05-18T01:21:41Z-
dc.date.issued2016-
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2016, v. 103 n. 4, p. 1073-1082-
dc.identifier.issn0002-9165-
dc.identifier.urihttp://hdl.handle.net/10722/225478-
dc.description.abstractBACKGROUND: Elevated maternal blood glucose concentrations may contribute to macrosomia, adiposity, and poorer vascular health in the offspring. OBJECTIVE: The aim was to explore the effect of a low-glycemic index (low-GI) diet during pregnancy on offspring growth, adiposity, and arterial wall thickness during infancy. DESIGN: This was a longitudinal follow-up study in a self-selected subgroup of mother-infant pairs (n= 59) participating in a larger randomized trial comparing the effects on perinatal outcomes of a low-GI diet and a conventional high-fiber (HF) diet during pregnancy. Infant anthropometric measurements were taken every month for 6 mo and then at 9 and 12 mo of age. Adiposity was assessed at birth and at 3 mo by air-displacement plethysmography by using the Pea Pod system (Cosmed) and at 6 and 12 mo by bioimpedance analysis (Bodystat). Aortic intima-media thickness was assessed at 12 mo by high-resolution ultrasound (Philips). RESULTS: Maternal dietary GI was lower in the low-GI group than in the HF group (51 ± 1 compared with 57 ± 1;P< 0.001). No differences in neonatal outcomes were observed in the main trial. In the self-selected subsample, birth weight and lengthzscores were lower in the low-GI group than in the HF group (birth weightzscore: 0.2 ± 0.2 compared with 0.7 ± 0.2, respectively;P= 0.04; birth lengthzscore: 0.3 ± 0.2 compared with 0.9 ± 0.2, respectively;P= 0.04), but adiposity from birth to 12 mo of age and growth trajectories from 1 to 12 mo of age were similar. Aortic intima-media thickness was lower in the low-GI group than in the HF group (657 ±12 compared with 696 ± 12 μm, respectively;P= 0.02), which was partly mediated by differences in birth weight. CONCLUSION: In women at risk of gestational diabetes mellitus, a low-GI diet influences offspring birth weight, birth length, and arterial wall thickness in early childhood, but not adiposity or growth trajectory during the first year of life. This trial was registered atanzctr.orgau as ACTRN12610000681055.-
dc.languageeng-
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/-
dc.relation.ispartofAmerican Journal of Clinical Nutrition-
dc.subjectBody composition-
dc.subjectGestational diabetes mellitus-
dc.subjectGlycemic index-
dc.subjectInfant-
dc.subjectIntima-media thickness-
dc.titleEffects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial-
dc.typeArticle-
dc.identifier.emailLouie, CYJ: h0115648@graduate.hku.hk-
dc.identifier.authorityLouie, CYJ=rp02118-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3945/ajcn.115.123695-
dc.identifier.pmid26936333-
dc.identifier.hkuros258413-
dc.identifier.volume103-
dc.identifier.issue4-
dc.identifier.spage1073-
dc.identifier.epage1082-
dc.publisher.placeUnited States-

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