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Article: Cardiovascular effects of Radix Stephaniae Tetrandreae - a comparison with its main component, tetrandrine

TitleCardiovascular effects of Radix Stephaniae Tetrandreae - a comparison with its main component, tetrandrine
Authors
KeywordsRadix Stephaniae Tetrandrae
Tetran-drine
Fangchinoline
Calcium
Arrhythmia
Issue Date2000
PublisherScience Press (科學出版社). The Journal's web site is located at http://www.chinaphar.com/
Citation
Acta Pharmacologica Sinica, 2000, v. 21 n. 12, p. 1083-1088 How to Cite?
中國藥理學報 (英文版), 2000, v. 21 n. 12, p. 1083-1088 How to Cite?
AbstractA comparison of the cardiovascular actions of the extract of Radix Stephaniae Tetrandrae (RST), the root of a Chinese herb Stephania tetrandra S Moore, in rats with those of tetrandrine (Tet), the best known active component of RST was reviewed. The RST extract inhibits Ca2+ influx into the myocyte and reduces protein release during reperfusion with a Ca2+ containing solution following perfusion with a Ca2+ free solution (Ca2+ paradox) , and arrhythmia during reperfusion in the isolated perfused heart. It also reduces the infarct size induced by ischemia/reperfusion in vitro and in vivo. In addition, the RST extract suppresses elevation of arterial blood pressure in DOCA-salt hypertensive rats. It does not further reduce the heart rate and coronary flow significantly during myocardial ischemia. The effects are similar to those of Tet. When compared with the same doses of Tet alone, the RST extract, of which 9 % is Tet, produces equally potent effects on infarction, arrhythmias, coronary flow and heart rate, and has a greater inhibitory effect on protein release during Ca2+ paradox. The combination at 1:1 ratio of Tet and fangchinoline (Fan), another main component, which constitutes 6 % of the RST extract and has no significant effects on the heart, produces comparable effects on protein release during Ca2+ paradox as Tet alone. The observations suggest that the efficacy of the RST extract cannot be accounted for byTet alone. Some of the effects may be due to an interaction between the components of the extract. The RST extract also produces similar effects as verapamil, a prototype Ca2+ channel antagonist widely used in the treatment of ischemic heart diseases and hypertension, except that verapamil, at 1 μmol/L, a concentration that produces similar cardiac effects as the RST extract, further reduces heart rate significantly during ischemia. So the RST extract may be a therapeutically better agent in the treatment of ischemic heart diseases and hypertension than Ca2+ channel antagonists because of the absence of the inhibitory effect on heart rate during myocardial ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/225468
ISSN
2000 Impact Factor: 0.485

 

DC FieldValueLanguage
dc.contributor.authorWong, TM-
dc.contributor.authorWu, S-
dc.contributor.authorYu, XC-
dc.contributor.authorLi, HY-
dc.date.accessioned2016-05-17T08:34:19Z-
dc.date.available2016-05-17T08:34:19Z-
dc.date.issued2000-
dc.identifier.citationActa Pharmacologica Sinica, 2000, v. 21 n. 12, p. 1083-1088-
dc.identifier.citation中國藥理學報 (英文版), 2000, v. 21 n. 12, p. 1083-1088-
dc.identifier.issn0253-9756-
dc.identifier.urihttp://hdl.handle.net/10722/225468-
dc.description.abstractA comparison of the cardiovascular actions of the extract of Radix Stephaniae Tetrandrae (RST), the root of a Chinese herb Stephania tetrandra S Moore, in rats with those of tetrandrine (Tet), the best known active component of RST was reviewed. The RST extract inhibits Ca2+ influx into the myocyte and reduces protein release during reperfusion with a Ca2+ containing solution following perfusion with a Ca2+ free solution (Ca2+ paradox) , and arrhythmia during reperfusion in the isolated perfused heart. It also reduces the infarct size induced by ischemia/reperfusion in vitro and in vivo. In addition, the RST extract suppresses elevation of arterial blood pressure in DOCA-salt hypertensive rats. It does not further reduce the heart rate and coronary flow significantly during myocardial ischemia. The effects are similar to those of Tet. When compared with the same doses of Tet alone, the RST extract, of which 9 % is Tet, produces equally potent effects on infarction, arrhythmias, coronary flow and heart rate, and has a greater inhibitory effect on protein release during Ca2+ paradox. The combination at 1:1 ratio of Tet and fangchinoline (Fan), another main component, which constitutes 6 % of the RST extract and has no significant effects on the heart, produces comparable effects on protein release during Ca2+ paradox as Tet alone. The observations suggest that the efficacy of the RST extract cannot be accounted for byTet alone. Some of the effects may be due to an interaction between the components of the extract. The RST extract also produces similar effects as verapamil, a prototype Ca2+ channel antagonist widely used in the treatment of ischemic heart diseases and hypertension, except that verapamil, at 1 μmol/L, a concentration that produces similar cardiac effects as the RST extract, further reduces heart rate significantly during ischemia. So the RST extract may be a therapeutically better agent in the treatment of ischemic heart diseases and hypertension than Ca2+ channel antagonists because of the absence of the inhibitory effect on heart rate during myocardial ischemia.-
dc.languageeng-
dc.publisherScience Press (科學出版社). The Journal's web site is located at http://www.chinaphar.com/-
dc.relation.ispartofActa Pharmacologica Sinica-
dc.relation.ispartof中國藥理學報 (英文版)-
dc.subjectRadix Stephaniae Tetrandrae-
dc.subjectTetran-drine-
dc.subjectFangchinoline-
dc.subjectCalcium-
dc.subjectArrhythmia-
dc.titleCardiovascular effects of Radix Stephaniae Tetrandreae - a comparison with its main component, tetrandrine-
dc.typeArticle-
dc.identifier.emailWong, TM: wongtakm@hkucc.hku.hk-
dc.identifier.emailWu, S: swua@hkucc.hku.hk-
dc.identifier.hkuros60005-
dc.identifier.volume21-
dc.identifier.issue12-
dc.identifier.spage1083-
dc.identifier.epage1088-
dc.publisher.placeBeijing (北京)-

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