File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: New lights in light's criteria

TitleNew lights in light's criteria
Authors
Issue Date2015
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
The 39th Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology, Brisbane, Australia, 30 May-1 June 2014. In Pathology, 2015, v. 47 suppl. 1, p. S83 How to Cite?
AbstractAIMS: Nuclear magnetic resonance (NMR) spectroscopy-based metabolome-wide association studies (MWAS) has been increasingly used in advanced laboratory medicine and biomarker discovery. Here, we will apply NMR-based MWAS to develop new diagnostic test for exudative and transudative pleural effusions (PE) with improved accuracy. METHODS: PE will be classified into exudates and transudates according to the etiology and analyzed using 1H-NMR spectroscopy (600MHz). Biomarkers will be determined using MWAS using Receiver Operating Characteristic Curve Explorer and Tester (ROCCET) and filtered using a metabolome-wide significance level (MWSL) at p-value < 4×10−6. RESULTS: There were 50 exudates and 17 transudates. Using MWAS, lipoprotein was determined to be the best biomarker that differentiated exudates from transudates (p-value: 1.01×10−10) with an area-under-ROC curve of 0.96 (95% CI: 0.89–0.99), sensitivity of 98% and specificity of 88%. The diagnostic performance is superior to the current standard, Light’s criteria which showed a specificity of 65% despite the same sensitivity at 98%. DISCUSSION: The high level of lipoproteins in exudates is related to the larger capillary pore-size secondary to inflammation. In contrast, without inflammation, the capillary pore-size remains intact in transudates. We envisage NMR-based lipoprotein profiling will be a powerful tool for pleural capillary pore-size estimation and will become a new standard. (C) 2015 Royal College of Pathologists of Australasia
DescriptionThis journal suppl. entitled: Australasian Division of the International Academy of Pathology Abstracts 39th Annual Scientific Meeting 2014
Persistent Identifierhttp://hdl.handle.net/10722/225416
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049

 

DC FieldValueLanguage
dc.contributor.authorLaw, CY-
dc.contributor.authorLam, CW-
dc.date.accessioned2016-05-12T04:33:58Z-
dc.date.available2016-05-12T04:33:58Z-
dc.date.issued2015-
dc.identifier.citationThe 39th Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology, Brisbane, Australia, 30 May-1 June 2014. In Pathology, 2015, v. 47 suppl. 1, p. S83-
dc.identifier.issn0031-3025-
dc.identifier.urihttp://hdl.handle.net/10722/225416-
dc.descriptionThis journal suppl. entitled: Australasian Division of the International Academy of Pathology Abstracts 39th Annual Scientific Meeting 2014-
dc.description.abstractAIMS: Nuclear magnetic resonance (NMR) spectroscopy-based metabolome-wide association studies (MWAS) has been increasingly used in advanced laboratory medicine and biomarker discovery. Here, we will apply NMR-based MWAS to develop new diagnostic test for exudative and transudative pleural effusions (PE) with improved accuracy. METHODS: PE will be classified into exudates and transudates according to the etiology and analyzed using 1H-NMR spectroscopy (600MHz). Biomarkers will be determined using MWAS using Receiver Operating Characteristic Curve Explorer and Tester (ROCCET) and filtered using a metabolome-wide significance level (MWSL) at p-value < 4×10−6. RESULTS: There were 50 exudates and 17 transudates. Using MWAS, lipoprotein was determined to be the best biomarker that differentiated exudates from transudates (p-value: 1.01×10−10) with an area-under-ROC curve of 0.96 (95% CI: 0.89–0.99), sensitivity of 98% and specificity of 88%. The diagnostic performance is superior to the current standard, Light’s criteria which showed a specificity of 65% despite the same sensitivity at 98%. DISCUSSION: The high level of lipoproteins in exudates is related to the larger capillary pore-size secondary to inflammation. In contrast, without inflammation, the capillary pore-size remains intact in transudates. We envisage NMR-based lipoprotein profiling will be a powerful tool for pleural capillary pore-size estimation and will become a new standard. (C) 2015 Royal College of Pathologists of Australasia-
dc.languageeng-
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp-
dc.relation.ispartofPathology-
dc.rightsPathology. Copyright © Informa Healthcare.-
dc.titleNew lights in light's criteria-
dc.typeConference_Paper-
dc.identifier.emailLaw, CY: ericlaw@hku.hk-
dc.identifier.emailLam, CW: ching-wanlam@pathology.hku.hk-
dc.identifier.authorityLaw, CY=rp01586-
dc.identifier.authorityLam, CW=rp00260-
dc.identifier.doi10.1097/01.PAT.0000461561.92836.8b-
dc.identifier.volume47-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS83-
dc.identifier.epageS83-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats