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Article: Acute sporadic hepatitis E virus infection in southern China

TitleAcute sporadic hepatitis E virus infection in southern China
Authors
Issue Date1995
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal of Hepatology, 1995, v. 23 n. 3, p. 239-245 How to Cite?
AbstractBACKGROUND/AIMS: The hepatitis E virus is responsible for epidemic and sporadic hepatitis in northwestern China, but its role as a cause of acute sporadic hepatitis in southern China has not been reported. METHODS: We applied the most practical current methods for diagnosis of hepatitis E virus infection, IgM and IgG anti-HEV detection by enzyme linked immunosorbent assay, to investigate the prevalence of hepatitis E virus infection among acute sporadic hepatitis. RESULTS: Anti-HEV IgM was found in 1 of 26 (3.8%), 4 of 20 (20.0%), 4 of 19 (21.1%), and 51 of 142 (35.9%), with acute hepatitis A, B, C and non-ABC, respectively. Anti-HEV IgM was not detectable in healthy subjects, while IgG anti-HEV was found in 14 of 77 healthy subjects (18.2%) and was long-lasting. Ninety-one cases without any evidence of hepatitis A, B or C infections and anti-HEV IgM were tentatively classified as non-A, B, C, D, E (non-ABCDE) hepatitis. By comparison with non-ABCDE, cases with hepatitis E were more frequently icteric and exhibited higher alanine aminotransferase levels (92.2% vs. 45.1%, 770 iu/l vs 377 iu/l, respectively, p < 0.005). Chronic cases were not observed in hepatitis E virus infections. However, 14 of 91 (15.4%) cases with non-ABCDE developed to chronicity (p < 0.005). CONCLUSIONS: Hepatitis E virus infection is sporadic as well as endemic in southern China. Only IgM anti-HEV but not IgG anti-HEV can be used as an appropriate marker of acute hepatitis E virus infection. Superinfection of hepatitis E virus with other types of hepatitis viruses is frequent in this area. While the disease was associated with more severe clinical manifestations, patients usually recovered completely.
Persistent Identifierhttp://hdl.handle.net/10722/225160
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorTan, D-
dc.contributor.authorIm, SWK-
dc.contributor.authorYao, JL-
dc.contributor.authorNg, MH-
dc.date.accessioned2016-04-26T03:07:50Z-
dc.date.available2016-04-26T03:07:50Z-
dc.date.issued1995-
dc.identifier.citationJournal of Hepatology, 1995, v. 23 n. 3, p. 239-245-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/225160-
dc.description.abstractBACKGROUND/AIMS: The hepatitis E virus is responsible for epidemic and sporadic hepatitis in northwestern China, but its role as a cause of acute sporadic hepatitis in southern China has not been reported. METHODS: We applied the most practical current methods for diagnosis of hepatitis E virus infection, IgM and IgG anti-HEV detection by enzyme linked immunosorbent assay, to investigate the prevalence of hepatitis E virus infection among acute sporadic hepatitis. RESULTS: Anti-HEV IgM was found in 1 of 26 (3.8%), 4 of 20 (20.0%), 4 of 19 (21.1%), and 51 of 142 (35.9%), with acute hepatitis A, B, C and non-ABC, respectively. Anti-HEV IgM was not detectable in healthy subjects, while IgG anti-HEV was found in 14 of 77 healthy subjects (18.2%) and was long-lasting. Ninety-one cases without any evidence of hepatitis A, B or C infections and anti-HEV IgM were tentatively classified as non-A, B, C, D, E (non-ABCDE) hepatitis. By comparison with non-ABCDE, cases with hepatitis E were more frequently icteric and exhibited higher alanine aminotransferase levels (92.2% vs. 45.1%, 770 iu/l vs 377 iu/l, respectively, p < 0.005). Chronic cases were not observed in hepatitis E virus infections. However, 14 of 91 (15.4%) cases with non-ABCDE developed to chronicity (p < 0.005). CONCLUSIONS: Hepatitis E virus infection is sporadic as well as endemic in southern China. Only IgM anti-HEV but not IgG anti-HEV can be used as an appropriate marker of acute hepatitis E virus infection. Superinfection of hepatitis E virus with other types of hepatitis viruses is frequent in this area. While the disease was associated with more severe clinical manifestations, patients usually recovered completely.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatology-
dc.subject.meshHepatitis e - epidemiology - immunology-
dc.subject.meshEnzyme-linked immunosorbent assay-
dc.subject.meshAlanine transaminase - blood-
dc.subject.meshChina - epidemiology-
dc.subject.meshAcute disease-
dc.titleAcute sporadic hepatitis E virus infection in southern China-
dc.typeArticle-
dc.identifier.emailIm, SWK: swkim@hkucc.hku.hk-
dc.identifier.emailNg, MH: hrmmnmh@hkucc.hku.hk-
dc.identifier.doi10.1016/S0168-8278(95)80001-8-
dc.identifier.pmid8550986-
dc.identifier.scopuseid_2-s2.0-0029153216-
dc.identifier.hkuros4371-
dc.identifier.volume23-
dc.identifier.issue3-
dc.identifier.spage239-
dc.identifier.epage245-
dc.publisher.placeNetherlands-

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