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Article: A correlative study on the mechanism of adaptive cytoprotection against ethanol-induced gastric lesion formation in rats

TitleA correlative study on the mechanism of adaptive cytoprotection against ethanol-induced gastric lesion formation in rats
Authors
KeywordsAdaptive cytoprotection
Atropine
Ethanol
Gastric lesions
Hexamethonium
Issue Date1994
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal of Gastroenterology and Hepatology, 1994, v. 9 n. 5, p. 492-500 How to Cite?
AbstractThe protective effect of mild irritants against the subsequent gastric injury induced by necrotizing agents has been termed ‘adaptive cytoprotection'. In this study, the possible pathway and mechanisms of adaptive cytoprotection induced by 20% ethanol were investigated. An ex-vivo gastric chamber preparation was used. The gastric mucosa was exposed to 20% ethanol before subsequent administration of 100% ethanol 15 min later. Subdiaphragmatic vagotomy or drug pretreatment was carried out in order to elucidate the mechanisms of adaptive cytoprotection by 20% ethanol. The results showed that 20% ethanol pre-exposure significantly protected the gastric mucosa against damage caused by 100% ethanol. This protective action was completely abolished by atropine or lidocaine pretreatment, whereas vagotomy and hexamethonium failed to have a significant influence. The cytoprotective effect, however, was independent of the gastric secretory volume, titratable acid content, luminal soluble mucus level and gastric mucosal blood flow. Exposure of only half the gastric mucosa to the mild irritant resulted in the protection of both sides of the mucosa. All these findings indicate that the adaptive cytoprotection of 20% ethanol involves the participation of chemoreceptors and muscarinic receptors in the gastric mucosa. An internal enteric reflex arc, with transmission of signals within the gastric mucosa, may also contribute to the cytoprotective process of the mild irritant.
Persistent Identifierhttp://hdl.handle.net/10722/225155
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorKo, JKS-
dc.contributor.authorCho, CH-
dc.contributor.authorOgle, CW-
dc.date.accessioned2016-04-25T04:44:29Z-
dc.date.available2016-04-25T04:44:29Z-
dc.date.issued1994-
dc.identifier.citationJournal of Gastroenterology and Hepatology, 1994, v. 9 n. 5, p. 492-500-
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/225155-
dc.description.abstractThe protective effect of mild irritants against the subsequent gastric injury induced by necrotizing agents has been termed ‘adaptive cytoprotection'. In this study, the possible pathway and mechanisms of adaptive cytoprotection induced by 20% ethanol were investigated. An ex-vivo gastric chamber preparation was used. The gastric mucosa was exposed to 20% ethanol before subsequent administration of 100% ethanol 15 min later. Subdiaphragmatic vagotomy or drug pretreatment was carried out in order to elucidate the mechanisms of adaptive cytoprotection by 20% ethanol. The results showed that 20% ethanol pre-exposure significantly protected the gastric mucosa against damage caused by 100% ethanol. This protective action was completely abolished by atropine or lidocaine pretreatment, whereas vagotomy and hexamethonium failed to have a significant influence. The cytoprotective effect, however, was independent of the gastric secretory volume, titratable acid content, luminal soluble mucus level and gastric mucosal blood flow. Exposure of only half the gastric mucosa to the mild irritant resulted in the protection of both sides of the mucosa. All these findings indicate that the adaptive cytoprotection of 20% ethanol involves the participation of chemoreceptors and muscarinic receptors in the gastric mucosa. An internal enteric reflex arc, with transmission of signals within the gastric mucosa, may also contribute to the cytoprotective process of the mild irritant.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH-
dc.relation.ispartofJournal of Gastroenterology and Hepatology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. -
dc.subjectAdaptive cytoprotection-
dc.subjectAtropine-
dc.subjectEthanol-
dc.subjectGastric lesions-
dc.subjectHexamethonium-
dc.titleA correlative study on the mechanism of adaptive cytoprotection against ethanol-induced gastric lesion formation in rats-
dc.typeArticle-
dc.identifier.emailKo, JKS: jksko@hkucc.hku.hk-
dc.identifier.emailCho, CH: chcho@hkusua.hku.hk-
dc.identifier.doi10.1111/j.1440-1746.1994.tb01280.x-
dc.identifier.hkuros3579-
dc.identifier.volume9-
dc.identifier.issue5-
dc.identifier.spage492-
dc.identifier.epage500-
dc.publisher.placeAustralia-

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