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Article: A stochastic model of fragment formation when DNA replicates

TitleA stochastic model of fragment formation when DNA replicates
Authors
KeywordsDNA replication
Renewal equation
Okazaki fragment
Issue Date1994
PublisherApplied Probability Trust. The Journal's web site is located at http://www.shef.ac.uk/uni/companies/apt/ap.html
Citation
Journal of Applied Probability, 1994, v. 31 n. 2, p. 301-308 How to Cite?
AbstractThe double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key 'sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain 'islands' of newly replicated DNA developed at the randomly located 'sites'. These islands, which have been observed experimentally, are called Okazaki fragments.
Persistent Identifierhttp://hdl.handle.net/10722/225140
ISSN
2015 Impact Factor: 0.665
2015 SCImago Journal Rankings: 0.742

 

DC FieldValueLanguage
dc.contributor.authorCowan, R-
dc.contributor.authorChiu, SN-
dc.date.accessioned2016-04-22T06:43:37Z-
dc.date.available2016-04-22T06:43:37Z-
dc.date.issued1994-
dc.identifier.citationJournal of Applied Probability, 1994, v. 31 n. 2, p. 301-308-
dc.identifier.issn0021-9002-
dc.identifier.urihttp://hdl.handle.net/10722/225140-
dc.description.abstractThe double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key 'sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain 'islands' of newly replicated DNA developed at the randomly located 'sites'. These islands, which have been observed experimentally, are called Okazaki fragments.-
dc.languageeng-
dc.publisherApplied Probability Trust. The Journal's web site is located at http://www.shef.ac.uk/uni/companies/apt/ap.html-
dc.relation.ispartofJournal of Applied Probability-
dc.rightsJournal of Applied Probability. Copyright © Applied Probability Trust.-
dc.subjectDNA replication-
dc.subjectRenewal equation-
dc.subjectOkazaki fragment-
dc.titleA stochastic model of fragment formation when DNA replicates-
dc.typeArticle-
dc.identifier.emailCowan, R: rcowan@hkursc.hku.hk-
dc.identifier.hkuros3941-
dc.identifier.volume31-
dc.identifier.issue2-
dc.identifier.spage301-
dc.identifier.epage308-
dc.publisher.placeUnited Kingdom-

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