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Article: The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity

TitleThe association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity
Authors
Keywordsinsulin resistance
insulin receptor
liver
PIKE-A
Issue Date2011
Citation
EMBO Reports, 2011, v. 12, n. 8, p. 847-854 How to Cite?
AbstractDysfunction of hepatic insulin receptor tyrosine kinase (IRTK) causes the development of type 2 diabetes. However, the molecular mechanism regulating IRTK activity in the liver remains poorly understood. Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enhancer of hepatic IRTK. Liver-specific Pike-knockout (LPKO) mice display glucose intolerance with impaired hepatic insulin sensitivity. Specifically, insulin-provoked phosphoinositide 3-kinase/Akt signalling is diminished in the liver of LPKO mice, leading to the failure of insulin-suppressed gluconeogenesis and hyperglycaemia. Thus, hepatic PIKE-A has a key role in mediating insulin signal transduction and regulating glucose homeostasis in the liver. © 2011 European Molecular Biology Organization.
Persistent Identifierhttp://hdl.handle.net/10722/225089
ISSN
2015 Impact Factor: 7.739
2015 SCImago Journal Rankings: 4.291

 

DC FieldValueLanguage
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorLiu, Xia-
dc.contributor.authorHe, Kunyan-
dc.contributor.authorQi, Qi-
dc.contributor.authorJung, Dae Y.-
dc.contributor.authorKim, Jason K.-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:45Z-
dc.date.available2016-04-18T11:16:45Z-
dc.date.issued2011-
dc.identifier.citationEMBO Reports, 2011, v. 12, n. 8, p. 847-854-
dc.identifier.issn1469-221X-
dc.identifier.urihttp://hdl.handle.net/10722/225089-
dc.description.abstractDysfunction of hepatic insulin receptor tyrosine kinase (IRTK) causes the development of type 2 diabetes. However, the molecular mechanism regulating IRTK activity in the liver remains poorly understood. Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enhancer of hepatic IRTK. Liver-specific Pike-knockout (LPKO) mice display glucose intolerance with impaired hepatic insulin sensitivity. Specifically, insulin-provoked phosphoinositide 3-kinase/Akt signalling is diminished in the liver of LPKO mice, leading to the failure of insulin-suppressed gluconeogenesis and hyperglycaemia. Thus, hepatic PIKE-A has a key role in mediating insulin signal transduction and regulating glucose homeostasis in the liver. © 2011 European Molecular Biology Organization.-
dc.languageeng-
dc.relation.ispartofEMBO Reports-
dc.subjectinsulin resistance-
dc.subjectinsulin receptor-
dc.subjectliver-
dc.subjectPIKE-A-
dc.titleThe association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1038/embor.2011.108-
dc.identifier.pmid21720388-
dc.identifier.scopuseid_2-s2.0-79961021544-
dc.identifier.volume12-
dc.identifier.issue8-
dc.identifier.spage847-
dc.identifier.epage854-
dc.identifier.eissn1469-3178-

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