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Article: Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex

TitlePhosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex
Authors
Issue Date2011
Citation
Journal of Neuroscience, 2011, v. 31, n. 22, p. 8083-8092 How to Cite?
AbstractPhosphoinositide 3-kinase enhancer (PIKE) binds and enhances phosphatidylinositol 3-kinase (PI3K)/Akt activities. However, its physiological functions in brain have never been explored. Here we show that PIKE is important in regulating the neuronal survival and development of neocortex. During development, enhanced apoptosis is observed in the ventricular zone of PIKE knock-out (PIKE-/-) cortex. Moreover, PIKE-/-neurons show reduced dendritic complexity, dendritic branch length, and soma size. These defects are due to the reduced PI3K/Akt activities in PIKE-/- neurons, as the impaired dendritic arborization can be rescued when PI3K/Akt cascade is augmented in vitro or in PIKE-/-PTEN-/- double-knock-out mice. Interestingly, PIKE-/- mice display behavioral abnormality in locomotion and spatial navigation. Because of the diminished PI3K/Akt activities, PIKE-/- neurons are more vulnerable to glutamateor stroke-induced neuronal cell death. Together, our data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt pathway. © 2011 the authors.
Persistent Identifierhttp://hdl.handle.net/10722/225088
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105

 

DC FieldValueLanguage
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorLiu, Xia-
dc.contributor.authorPradoldej, Sompol-
dc.contributor.authorHao, Chunhai-
dc.contributor.authorAn, Jie-
dc.contributor.authorYepes, Manuel-
dc.contributor.authorLuo, Hongbo R.-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:45Z-
dc.date.available2016-04-18T11:16:45Z-
dc.date.issued2011-
dc.identifier.citationJournal of Neuroscience, 2011, v. 31, n. 22, p. 8083-8092-
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10722/225088-
dc.description.abstractPhosphoinositide 3-kinase enhancer (PIKE) binds and enhances phosphatidylinositol 3-kinase (PI3K)/Akt activities. However, its physiological functions in brain have never been explored. Here we show that PIKE is important in regulating the neuronal survival and development of neocortex. During development, enhanced apoptosis is observed in the ventricular zone of PIKE knock-out (PIKE-/-) cortex. Moreover, PIKE-/-neurons show reduced dendritic complexity, dendritic branch length, and soma size. These defects are due to the reduced PI3K/Akt activities in PIKE-/- neurons, as the impaired dendritic arborization can be rescued when PI3K/Akt cascade is augmented in vitro or in PIKE-/-PTEN-/- double-knock-out mice. Interestingly, PIKE-/- mice display behavioral abnormality in locomotion and spatial navigation. Because of the diminished PI3K/Akt activities, PIKE-/- neurons are more vulnerable to glutamateor stroke-induced neuronal cell death. Together, our data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt pathway. © 2011 the authors.-
dc.languageeng-
dc.relation.ispartofJournal of Neuroscience-
dc.titlePhosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1523/JNEUROSCI.1129-11.2011-
dc.identifier.pmid21632930-
dc.identifier.scopuseid_2-s2.0-79958051229-
dc.identifier.volume31-
dc.identifier.issue22-
dc.identifier.spage8083-
dc.identifier.epage8092-
dc.identifier.eissn1529-2401-

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