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Article: Phosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer?

TitlePhosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer?
Authors
KeywordsGTPase
Akt
PIKE
PI3K
neuron
Issue Date2012
Citation
Reviews in the Neurosciences, 2012, v. 23, n. 2, p. 153-161 How to Cite?
AbstractSince its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders. © 2012 by Walter de Gruyter Berlin Boston.
Persistent Identifierhttp://hdl.handle.net/10722/225034
ISSN
2015 Impact Factor: 3.198
2015 SCImago Journal Rankings: 1.605

 

DC FieldValueLanguage
dc.contributor.authorChan, Chi Bun-
dc.contributor.authorYe, Keqiang-
dc.date.accessioned2016-04-18T11:16:34Z-
dc.date.available2016-04-18T11:16:34Z-
dc.date.issued2012-
dc.identifier.citationReviews in the Neurosciences, 2012, v. 23, n. 2, p. 153-161-
dc.identifier.issn0334-1763-
dc.identifier.urihttp://hdl.handle.net/10722/225034-
dc.description.abstractSince its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders. © 2012 by Walter de Gruyter Berlin Boston.-
dc.languageeng-
dc.relation.ispartofReviews in the Neurosciences-
dc.subjectGTPase-
dc.subjectAkt-
dc.subjectPIKE-
dc.subjectPI3K-
dc.subjectneuron-
dc.titlePhosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer?-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1515/revneuro-2011-0066-
dc.identifier.pmid22499674-
dc.identifier.scopuseid_2-s2.0-84861051747-
dc.identifier.volume23-
dc.identifier.issue2-
dc.identifier.spage153-
dc.identifier.epage161-

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