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Article: Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders

TitleNosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders
Authors
Issue Date2016
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2016, v. 22 n. 4, p. 598-607 How to Cite?
AbstractA nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man with chronic lymphocytic leukemia who had been occupationally exposed to poultry. He had co-infection with H7N9 and pH1N1 viruses. A 71-year-old man with polycythemia vera who was in the same ward as the index case-patient for 6 days acquired infection with H7N9 and pH1N1 viruses. The incubation period for the second case-patient was estimated to be <4 days. Both case-patients died of multiple organ failure. Virus genetic sequences from the 2 case-patients were identical. Of 103 close contacts, none had acute respiratory symptoms; all were negative for H7N9 virus. Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. These findings strongly suggest limited nosocomial co-transmission of H7N9 and pH1N1 viruses from 1 immunocompromised patient to another.
Persistent Identifierhttp://hdl.handle.net/10722/224842
ISSN
2015 Impact Factor: 6.994
2015 SCImago Journal Rankings: 3.023
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorChen, H-
dc.contributor.authorLiu, S-
dc.contributor.authorLiu, J-
dc.contributor.authorChai, C-
dc.contributor.authorMao, H-
dc.contributor.authorYu, Z-
dc.contributor.authorTang, Y-
dc.contributor.authorZhu, G-
dc.contributor.authorChen, HX-
dc.contributor.authorZhu, C-
dc.contributor.authorShao, H-
dc.contributor.authorTan, S-
dc.contributor.authorWang, Q-
dc.contributor.authorBi, Y-
dc.contributor.authorZou, Z-
dc.contributor.authorLiu, G-
dc.contributor.authorJin, T-
dc.contributor.authorJiang, C-
dc.contributor.authorGao, GF-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorYu, H-
dc.contributor.authorChen, E-
dc.date.accessioned2016-04-18T03:33:24Z-
dc.date.available2016-04-18T03:33:24Z-
dc.date.issued2016-
dc.identifier.citationEmerging Infectious Diseases, 2016, v. 22 n. 4, p. 598-607-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/224842-
dc.description.abstractA nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man with chronic lymphocytic leukemia who had been occupationally exposed to poultry. He had co-infection with H7N9 and pH1N1 viruses. A 71-year-old man with polycythemia vera who was in the same ward as the index case-patient for 6 days acquired infection with H7N9 and pH1N1 viruses. The incubation period for the second case-patient was estimated to be <4 days. Both case-patients died of multiple organ failure. Virus genetic sequences from the 2 case-patients were identical. Of 103 close contacts, none had acute respiratory symptoms; all were negative for H7N9 virus. Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. These findings strongly suggest limited nosocomial co-transmission of H7N9 and pH1N1 viruses from 1 immunocompromised patient to another.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders-
dc.typeArticle-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2204.151561-
dc.identifier.pmid26982379-
dc.identifier.pmcidPMC4806937-
dc.identifier.hkuros257597-
dc.identifier.volume22-
dc.identifier.issue4-
dc.identifier.spage598-
dc.identifier.epage607-
dc.publisher.placeUnited States-

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