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Article: Adaptive gastric mucosal cytoprotection in rats: different modes of action by three mild irritants

TitleAdaptive gastric mucosal cytoprotection in rats: different modes of action by three mild irritants
Authors
Issue Date1996
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 1996, v. 57 n. 1, p. 54-59 How to Cite?
AbstractThe mechanisms of adaptive mucosal cytoprotection by mild irritants were investigated in rats. In an ex vivo chamber preparation, application of 20% ethanol, 5% NaCl or 0.3 M HCl to the posterior side of the mucosa significantly protected that side of the stomach against mucosal damage caused by subsequent exposure to 100% ethanol, with contralateral transmission of protection to the anterior side by 20% ethanol and 0.3 M HCl. Atropine or lidocaine significantly reversed the cytoprotection of 20% ethanol. Bilateral vagotomy partially prevented the antilesion action of 20% ethanol, and completely prevented the action of 0.3 M HCl. However, the three mild irritants did not affect gastric mucosal blood flow, but restored the ion transport mechanism which was depressed by ethanol. It is therefore concluded that the three mild irritants have their own distinctive cytoprotective mechanisms against ethanol ulceration, which is predominantly not mediated by effects on the vascular system of the gastric mucosa.
Persistent Identifierhttp://hdl.handle.net/10722/224769
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953

 

DC FieldValueLanguage
dc.contributor.authorKo, JKS-
dc.contributor.authorCho, CH-
dc.date.accessioned2016-04-14T07:52:08Z-
dc.date.available2016-04-14T07:52:08Z-
dc.date.issued1996-
dc.identifier.citationDigestion, 1996, v. 57 n. 1, p. 54-59-
dc.identifier.issn0012-2823-
dc.identifier.urihttp://hdl.handle.net/10722/224769-
dc.description.abstractThe mechanisms of adaptive mucosal cytoprotection by mild irritants were investigated in rats. In an ex vivo chamber preparation, application of 20% ethanol, 5% NaCl or 0.3 M HCl to the posterior side of the mucosa significantly protected that side of the stomach against mucosal damage caused by subsequent exposure to 100% ethanol, with contralateral transmission of protection to the anterior side by 20% ethanol and 0.3 M HCl. Atropine or lidocaine significantly reversed the cytoprotection of 20% ethanol. Bilateral vagotomy partially prevented the antilesion action of 20% ethanol, and completely prevented the action of 0.3 M HCl. However, the three mild irritants did not affect gastric mucosal blood flow, but restored the ion transport mechanism which was depressed by ethanol. It is therefore concluded that the three mild irritants have their own distinctive cytoprotective mechanisms against ethanol ulceration, which is predominantly not mediated by effects on the vascular system of the gastric mucosa.-
dc.languageeng-
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG-
dc.relation.ispartofDigestion-
dc.rightsDigestion. Copyright © S Karger AG.-
dc.subject.meshGastric mucosa - blood supply - drug effects - pathology-
dc.subject.meshStomach ulcer - drug therapy - pathology - physiopathology-
dc.subject.meshSodium chloride - pharmacology-
dc.subject.meshRegional blood flow - drug effects-
dc.subject.meshHydrochloric acid - pharmacology-
dc.titleAdaptive gastric mucosal cytoprotection in rats: different modes of action by three mild irritants-
dc.typeArticle-
dc.identifier.emailCho, CH: chcho@hkusua.hku.hk-
dc.identifier.doi10.1159/000201313-
dc.identifier.pmid8626049-
dc.identifier.hkuros9301-
dc.identifier.volume57-
dc.identifier.issue1-
dc.identifier.spage54-
dc.identifier.epage59-
dc.publisher.placeSwitzerland-

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