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Conference Paper: Central administration of secretin suppresses food intake in mice

TitleCentral administration of secretin suppresses food intake in mice
Authors
Issue Date2010
PublisherHumana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031
Citation
The 9th International Symposium on VIP, PACAP, and Related Peptides, Kagoshima, Japan, 5-8 October 2009. In Journal of Molecular Neuroscience, 2010, v. 42 n. 3, p. 285 How to Cite?
AbstractSecretin is released into the circulation postprandially from the duodenal S cells. The major functions of secretin originated from the gastrointestinal system are to delay gastric emptying, stimulate fluid secretion from pancreas and liver, and hence, optimize the digestion process. In our laboratory, secretin and its receptor have recently been identified in mice hypothalamus where it has long been considered as an important center in the regulation of energy homeostasis. By altering the rate at which nutrients are delivered to compartments of the alimentary canal and being highly expressed in hypothalamic nuclei, secretin could therefore be involved in appetite control. In this study, the functional role of secretin on feeding regulation was investigated. Intracerebroventricular (ICV) administration of secretin (0.15 nmol) into the lateral ventricle was found to suppress food intake in both fasted mice or ad libitum fed wild-type mice but not in fasted mice or ad libitum fed secretin receptor knockout mice (SCTR−/−). In addition, central administration of secretin could induce Fos expression in hypothalamic nuclei, including the paraventricular nucleus (PVN) and the arcuate nucleus (Arc). Consistent with these findings, ICV-secretin could also change expressions of appetite control proteins in various hypothalamic nuclei. It could activate proopiomelanocortin (POMC), reduce agoutirelated protein (AgRP) mRNA expression in the Arc, and increase thyrotropin-releasing hormone (TRH) transcripts in the PVN, while these effects of ICV-secretin were not found in SCTR−/−. Altogether, our data suggest that secretin, via its receptor, could inhibit food intake and that this action could be mediated by changing the expressions of POMC and AgRP in the Arc and TRH in the PVN.
DescriptionSession 5: Endocrine System and Metabolism: no. O13
This journal issue entitled: Special Issue: VIP, PACAP and Related Peptides
Persistent Identifierhttp://hdl.handle.net/10722/224421
ISSN
2015 Impact Factor: 2.352
2015 SCImago Journal Rankings: 0.988

 

DC FieldValueLanguage
dc.contributor.authorCheng, YY-
dc.contributor.authorChu, JYS-
dc.contributor.authorChow, BKC-
dc.date.accessioned2016-04-05T03:05:26Z-
dc.date.available2016-04-05T03:05:26Z-
dc.date.issued2010-
dc.identifier.citationThe 9th International Symposium on VIP, PACAP, and Related Peptides, Kagoshima, Japan, 5-8 October 2009. In Journal of Molecular Neuroscience, 2010, v. 42 n. 3, p. 285-
dc.identifier.issn0895-8696-
dc.identifier.urihttp://hdl.handle.net/10722/224421-
dc.descriptionSession 5: Endocrine System and Metabolism: no. O13-
dc.descriptionThis journal issue entitled: Special Issue: VIP, PACAP and Related Peptides-
dc.description.abstractSecretin is released into the circulation postprandially from the duodenal S cells. The major functions of secretin originated from the gastrointestinal system are to delay gastric emptying, stimulate fluid secretion from pancreas and liver, and hence, optimize the digestion process. In our laboratory, secretin and its receptor have recently been identified in mice hypothalamus where it has long been considered as an important center in the regulation of energy homeostasis. By altering the rate at which nutrients are delivered to compartments of the alimentary canal and being highly expressed in hypothalamic nuclei, secretin could therefore be involved in appetite control. In this study, the functional role of secretin on feeding regulation was investigated. Intracerebroventricular (ICV) administration of secretin (0.15 nmol) into the lateral ventricle was found to suppress food intake in both fasted mice or ad libitum fed wild-type mice but not in fasted mice or ad libitum fed secretin receptor knockout mice (SCTR−/−). In addition, central administration of secretin could induce Fos expression in hypothalamic nuclei, including the paraventricular nucleus (PVN) and the arcuate nucleus (Arc). Consistent with these findings, ICV-secretin could also change expressions of appetite control proteins in various hypothalamic nuclei. It could activate proopiomelanocortin (POMC), reduce agoutirelated protein (AgRP) mRNA expression in the Arc, and increase thyrotropin-releasing hormone (TRH) transcripts in the PVN, while these effects of ICV-secretin were not found in SCTR−/−. Altogether, our data suggest that secretin, via its receptor, could inhibit food intake and that this action could be mediated by changing the expressions of POMC and AgRP in the Arc and TRH in the PVN.-
dc.languageeng-
dc.publisherHumana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031-
dc.relation.ispartofJournal of Molecular Neuroscience-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s12031-009-9324-2-
dc.titleCentral administration of secretin suppresses food intake in mice-
dc.typeConference_Paper-
dc.identifier.emailChu, JYS: hitan@graduate.hku.hk-
dc.identifier.emailChow, BKC: bkcc@hkusua.hku.hk-
dc.identifier.authorityChu, JYS=rp00684-
dc.identifier.authorityChow, BKC=rp00681-
dc.identifier.doi10.1007/s12031-009-9324-2-
dc.identifier.hkuros181135-
dc.identifier.volume42-
dc.identifier.issue3-
dc.identifier.spage285-
dc.identifier.epage285-
dc.publisher.placeUnited States-

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