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Article: Cardiac effects of the extract and active components of radix stephaniae tetrandrae: I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox

TitleCardiac effects of the extract and active components of radix stephaniae tetrandrae: I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2001, v. 68 n. 25, p. 2853-2861 How to Cite?
AbstractThe present study was designed to compare the cardiac actions of the extract and individual components, tetrandrine (Tet) and fangchinoline (Fan), of Radix stephaniae tetrandrae (RST). We measured the electrically induced [Ca2+]i transient in single rat ventricular myocytes and protein release following perfusion with a Ca2+ free solution (the Ca2+ paradox) from the isolated perfused rat heart, both of which are known to relate to Ca2+ influx. We found that Tet inhibited both electrically induced [Ca2+]i transient and protein release during the Ca2+ paradox, while Fan had no significant effects. The RST extract containing 9% Tet and 6% Fan by weight also affected the [Ca2+]i transient, and was only slightly, though significantly, less effective/potent than Tet alone. On the other hand, RST extract had a significantly greater inhibitory effect on protein release during the Ca2+ paradox than Tet alone. The observations suggest that the RST extract, which contains a mixture of components, may have more potent effects in the heart than its main active component.
Persistent Identifierhttp://hdl.handle.net/10722/224116
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorWu, S-
dc.contributor.authorXu, XC-
dc.contributor.authorShan, J-
dc.contributor.authorWong, TM-
dc.contributor.authorChen, CF-
dc.contributor.authorPang, KT-
dc.date.accessioned2016-03-24T02:57:41Z-
dc.date.available2016-03-24T02:57:41Z-
dc.date.issued2001-
dc.identifier.citationLife Sciences, 2001, v. 68 n. 25, p. 2853-2861-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/224116-
dc.description.abstractThe present study was designed to compare the cardiac actions of the extract and individual components, tetrandrine (Tet) and fangchinoline (Fan), of Radix stephaniae tetrandrae (RST). We measured the electrically induced [Ca2+]i transient in single rat ventricular myocytes and protein release following perfusion with a Ca2+ free solution (the Ca2+ paradox) from the isolated perfused rat heart, both of which are known to relate to Ca2+ influx. We found that Tet inhibited both electrically induced [Ca2+]i transient and protein release during the Ca2+ paradox, while Fan had no significant effects. The RST extract containing 9% Tet and 6% Fan by weight also affected the [Ca2+]i transient, and was only slightly, though significantly, less effective/potent than Tet alone. On the other hand, RST extract had a significantly greater inhibitory effect on protein release during the Ca2+ paradox than Tet alone. The observations suggest that the RST extract, which contains a mixture of components, may have more potent effects in the heart than its main active component.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.subject.meshBenzylisoquinolines-
dc.subject.meshCalcium - metabolism-
dc.subject.meshCalcium Channel Blockers - pharmacology-
dc.subject.meshDrugs, Chinese Herbal - pharmacology-
dc.subject.meshHeart Ventricles - drug effects - metabolism-
dc.titleCardiac effects of the extract and active components of radix stephaniae tetrandrae: I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox-
dc.typeArticle-
dc.identifier.emailWu, S: swua@hkucc.hku.hk-
dc.identifier.emailWong, TM: wongtakm@hkucc.hku.hk-
dc.identifier.doi10.1016/S0024-3205(01)01068-2-
dc.identifier.pmid11432451-
dc.identifier.scopuseid_2-s2.0-0035844010-
dc.identifier.hkuros60022-
dc.identifier.volume68-
dc.identifier.issue25-
dc.identifier.spage2853-
dc.identifier.epage2861-
dc.publisher.placeUnited States-

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