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Article: Biomimetic synthesis of PEC-HA composite analogous to bone

TitleBiomimetic synthesis of PEC-HA composite analogous to bone
Authors
Issue Date2007
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Key Engineering Materials, 2007, v. 336-338, p. 1699-1702 How to Cite?
AbstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6mM, Ca/P = 1.67) was added into PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC-HA, has a complicated, hierarchical porous structure that is expected to have high bio-compatibity and that may be of use as a carrier for controlled-release therapetic agents.
Persistent Identifierhttp://hdl.handle.net/10722/224088
ISSN
2005 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.173

 

DC FieldValueLanguage
dc.contributor.authorLi, QL-
dc.contributor.authorChen, ZQ-
dc.contributor.authorDarvell, BW-
dc.contributor.authorZeng, Q-
dc.contributor.authorLi, G-
dc.contributor.authorOu, GM-
dc.contributor.authorWu, MY-
dc.date.accessioned2016-03-23T02:16:46Z-
dc.date.available2016-03-23T02:16:46Z-
dc.date.issued2007-
dc.identifier.citationKey Engineering Materials, 2007, v. 336-338, p. 1699-1702-
dc.identifier.issn1013-9826-
dc.identifier.urihttp://hdl.handle.net/10722/224088-
dc.description.abstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6mM, Ca/P = 1.67) was added into PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC-HA, has a complicated, hierarchical porous structure that is expected to have high bio-compatibity and that may be of use as a carrier for controlled-release therapetic agents.-
dc.languageeng-
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net-
dc.relation.ispartofKey Engineering Materials-
dc.titleBiomimetic synthesis of PEC-HA composite analogous to bone-
dc.typeArticle-
dc.identifier.emailDarvell, BW: hrdubwd@hkucc.hku.hk-
dc.identifier.authorityDarvell, BW=rp00007-
dc.identifier.doi10.4028/www.scientific.net/KEM.336-338.1699-
dc.identifier.hkuros128858-
dc.identifier.volume336-338-
dc.identifier.spage1699-
dc.identifier.epage1702-
dc.publisher.placeSwitzerland-

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