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Article: Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?

TitleAdult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?
Authors
Issue Date2015
PublisherBentham Science Publishers Ltd.. The Journal's web site is located at http://www.bentham.org/cdtcnsnd
Citation
C N S & Neurological Disorders - Drug Targets, 2015, v. 14 n. 9, p. 1129-1144 How to Cite?
AbstractPhysical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocytesecreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity. The present review introduces the previously-reported functions of adult hippocampal neurogenesis and adiponectin, and discusses the potential relevance of adiponectin signaling in exercise-induced neural changes. Revealing these novel biological effects of adiponectin in the brain may help hunt reliable biomarkers to better guide the anti-depressive therapy with exercise intervention; meanwhile, pharmaceutical agents that raise endogenous levels of adiponectin or mimic its biological effects might serve as a replacement for physical exercise.
Persistent Identifierhttp://hdl.handle.net/10722/223987
ISSN
2015 Impact Factor: 2.188
2015 SCImago Journal Rankings: 0.883

 

DC FieldValueLanguage
dc.contributor.authorLi, A-
dc.contributor.authorYau, SY-
dc.contributor.authorMachado, S-
dc.contributor.authorYuan, TF-
dc.contributor.authorSo, KF-
dc.date.accessioned2016-03-18T02:33:21Z-
dc.date.available2016-03-18T02:33:21Z-
dc.date.issued2015-
dc.identifier.citationC N S & Neurological Disorders - Drug Targets, 2015, v. 14 n. 9, p. 1129-1144-
dc.identifier.issn1871-5273-
dc.identifier.urihttp://hdl.handle.net/10722/223987-
dc.description.abstractPhysical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocytesecreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity. The present review introduces the previously-reported functions of adult hippocampal neurogenesis and adiponectin, and discusses the potential relevance of adiponectin signaling in exercise-induced neural changes. Revealing these novel biological effects of adiponectin in the brain may help hunt reliable biomarkers to better guide the anti-depressive therapy with exercise intervention; meanwhile, pharmaceutical agents that raise endogenous levels of adiponectin or mimic its biological effects might serve as a replacement for physical exercise.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd.. The Journal's web site is located at http://www.bentham.org/cdtcnsnd-
dc.relation.ispartofC N S & Neurological Disorders - Drug Targets-
dc.titleAdult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?-
dc.typeArticle-
dc.identifier.emailLi, A: anglihk@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.doi10.2174/1871527315666151111125533#sthash.pf3TUqxm.dpuf-
dc.identifier.pmid26556072-
dc.identifier.hkuros257205-
dc.identifier.volume14-
dc.identifier.issue9-
dc.identifier.spage1129-
dc.identifier.epage1144-
dc.publisher.placeNetherlands-

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