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Article: Application of proteomics in the study of tumor metastasis

TitleApplication of proteomics in the study of tumor metastasis
Authors
KeywordsProteomics
Metastasis
Tumor
Mechanism
Protein
Issue Date2004
PublisherScience Press.
Citation
Genomics Proteomics & Bioinformatics, 2004, v. 2 n. 3, p. 152-166 How to Cite?
AbstractTumor metastasis is the dominant cause of death in cancer patients. However, the molecular and cellular mechanisms underlying tumor metastasis are still elusive. The identification of protein molecules with their expressions correlated to the metastatic process would help to understand the metastatic mechanisms and thus facilitate the development of strategies for the therapeutic interventions and clinical management of cancer. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomic technology has been widely used in biomarker discovery and pathogenetic studies including tumor metastasis. This article provides a brief review of the application of proteomics in identifying molecular factors in tumor metastasis process. The combination of proteomics with other experimental approaches in biochemistry, cell biology, molecular genetics and chemistry, together with the development of new technologies and improvements in existing methodologies will continue to extend its application in studying cancer metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/223546
ISSN
2015 SCImago Journal Rankings: 1.058

 

DC FieldValueLanguage
dc.contributor.authorCai, Z-
dc.contributor.authorChiu, JF-
dc.contributor.authorHe, QY-
dc.date.accessioned2016-03-02T07:46:27Z-
dc.date.available2016-03-02T07:46:27Z-
dc.date.issued2004-
dc.identifier.citationGenomics Proteomics & Bioinformatics, 2004, v. 2 n. 3, p. 152-166-
dc.identifier.issn1672-0229-
dc.identifier.urihttp://hdl.handle.net/10722/223546-
dc.description.abstractTumor metastasis is the dominant cause of death in cancer patients. However, the molecular and cellular mechanisms underlying tumor metastasis are still elusive. The identification of protein molecules with their expressions correlated to the metastatic process would help to understand the metastatic mechanisms and thus facilitate the development of strategies for the therapeutic interventions and clinical management of cancer. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomic technology has been widely used in biomarker discovery and pathogenetic studies including tumor metastasis. This article provides a brief review of the application of proteomics in identifying molecular factors in tumor metastasis process. The combination of proteomics with other experimental approaches in biochemistry, cell biology, molecular genetics and chemistry, together with the development of new technologies and improvements in existing methodologies will continue to extend its application in studying cancer metastasis.-
dc.languageeng-
dc.publisherScience Press.-
dc.relation.ispartofGenomics Proteomics & Bioinformatics-
dc.subjectProteomics-
dc.subjectMetastasis-
dc.subjectTumor-
dc.subjectMechanism-
dc.subjectProtein-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshModels, Biological-
dc.subject.meshNeoplasm Metastasis - genetics-
dc.subject.meshOligonucleotide Array Sequence Analysis - methods-
dc.subject.meshProteomics - methods-
dc.titleApplication of proteomics in the study of tumor metastasis-
dc.typeArticle-
dc.identifier.emailChiu, JF: jfchiu@hkucc.hku.hk-
dc.identifier.emailHe, QY: qyhe@hkucc.hku.hk-
dc.identifier.pmid15862116-
dc.identifier.hkuros98456-
dc.identifier.volume2-
dc.identifier.issue3-
dc.identifier.spage152-
dc.identifier.epage166-
dc.publisher.placeChina-

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