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Article: Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma

TitleAlternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma
Authors
Issue Date2002
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2002, v. 62 n. 14, p. 4089-4094 How to Cite?
AbstractChromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. In a fraction of these translocations, the chromosomal breakpoint is located within the 5' noncoding region of the BCL-6 proto-oncogene where the BCL-6 major breakpoint region (MBR) maps. As a result of the translocation, BCL-6 expression is deregulated by promoter substitution. However, between 30 and 50% of lymphomas with cytogenetically detectable translocations affecting band 3q27 retain a germ-line configuration at the BCL-6 locus. To identify possible additional breakpoint clusters within 3q27, we cloned a t(3;14)(q27;q32) lymphoma without MBR rearrangement and found a novel breakpoint site located between 245 and 285 kb 5' to BCL-6. Breakpoints within this newly described region, which we called the alternative breakpoint region (ABR), were found to be recurrent in lymphomas carrying t(3q27) chromosomal translocations but devoid of BCL-6 MBR rearrangements. Comparative analysis of multiple lymphomas carrying rearrangements within the ABR showed that the breakpoints cluster within a 20-kb distance. Translocations involving the ABR may juxtapose BCL-6 to distantly acting, heterologous transcriptional regulatory elements which cause deregulation of the proto-oncogene. The identification of BCL-6 ABR provides new tools for the diagnosis of lymphomas carrying aberrations at 3q27 and deregulated BCL-6 genes.
Persistent Identifierhttp://hdl.handle.net/10722/222878
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorButler, MP-
dc.contributor.authorIida, S-
dc.contributor.authorCapello, D-
dc.contributor.authorRao, PH-
dc.contributor.authorRossi, D-
dc.contributor.authorNallasivam, P-
dc.contributor.authorLouie, DC-
dc.contributor.authorChaganti, S-
dc.contributor.authorAu, T-
dc.contributor.authorGascoyne, RD-
dc.contributor.authorGaidano, G-
dc.contributor.authorChaganti, RSK-
dc.contributor.authorDalla-Favera, R-
dc.date.accessioned2016-02-05T06:49:05Z-
dc.date.available2016-02-05T06:49:05Z-
dc.date.issued2002-
dc.identifier.citationCancer Research, 2002, v. 62 n. 14, p. 4089-4094-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/222878-
dc.description.abstractChromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. In a fraction of these translocations, the chromosomal breakpoint is located within the 5' noncoding region of the BCL-6 proto-oncogene where the BCL-6 major breakpoint region (MBR) maps. As a result of the translocation, BCL-6 expression is deregulated by promoter substitution. However, between 30 and 50% of lymphomas with cytogenetically detectable translocations affecting band 3q27 retain a germ-line configuration at the BCL-6 locus. To identify possible additional breakpoint clusters within 3q27, we cloned a t(3;14)(q27;q32) lymphoma without MBR rearrangement and found a novel breakpoint site located between 245 and 285 kb 5' to BCL-6. Breakpoints within this newly described region, which we called the alternative breakpoint region (ABR), were found to be recurrent in lymphomas carrying t(3q27) chromosomal translocations but devoid of BCL-6 MBR rearrangements. Comparative analysis of multiple lymphomas carrying rearrangements within the ABR showed that the breakpoints cluster within a 20-kb distance. Translocations involving the ABR may juxtapose BCL-6 to distantly acting, heterologous transcriptional regulatory elements which cause deregulation of the proto-oncogene. The identification of BCL-6 ABR provides new tools for the diagnosis of lymphomas carrying aberrations at 3q27 and deregulated BCL-6 genes.-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.subject.meshChromosomes, Human, Pair 3-
dc.subject.meshDNA-Binding Proteins - genetics-
dc.subject.meshLymphoma, B-Cell - genetics-
dc.subject.meshProto-Oncogene Proteins - genetics-
dc.subject.meshTranscription Factors - genetics-
dc.titleAlternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin’s Lymphoma-
dc.typeArticle-
dc.identifier.emailAu, T: auwing@hkucc.hku.hk-
dc.identifier.pmid12124346-
dc.identifier.hkuros77922-
dc.identifier.volume62-
dc.identifier.issue14-
dc.identifier.spage4089-
dc.identifier.epage4094-
dc.publisher.placeUnited States-

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