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Article: Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation

TitleArterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation
Authors
Issue Date1989
PublisherNature Publishing Group. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal of Pharmacology, 1989, v. 96 n. 4, p. 888-894 How to Cite?
Abstract1 The effect of acute or chronic morphine treatment on the changes in arterial noradrenaline and adrenaline levels in response to sympathetic nerve stimulation was studied in rats. 2 Rats which had been chronically treated with morphine in their drinking fluid for 21 days were shown to be morphine-tolerant, as revealed by the tail-immersion test for analgesia. 3 It was found that animals given either acute or chronic morphine treatment had similar basal concentrations of arterial catecholamines to their controls. 4 Sympathetic nerve stimulation produced significant increases in arterial noradrenaline and adrenaline levels in both the control and morphine-treated animals. However, the degree of arterial noradrenaline elevation was significantly less in morphine-tolerant animals. 5 This phenomenon was not observed in acutely morphine-treated rats or at 2 weeks following opiate withdrawal in animals which had been treated previously with morphine for 3 weeks. 6 The findings suggest that chronic morphine treatment in rats not only leads to opiate tolerance but also reduces catecholamine release in response to sympathetic nerve stimulation.
Persistent Identifierhttp://hdl.handle.net/10722/222859
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, CMK-
dc.contributor.authorDai, S-
dc.contributor.authorOgle, CW-
dc.date.accessioned2016-02-05T02:48:10Z-
dc.date.available2016-02-05T02:48:10Z-
dc.date.issued1989-
dc.identifier.citationBritish Journal of Pharmacology, 1989, v. 96 n. 4, p. 888-894-
dc.identifier.issn0007-1188-
dc.identifier.urihttp://hdl.handle.net/10722/222859-
dc.description.abstract1 The effect of acute or chronic morphine treatment on the changes in arterial noradrenaline and adrenaline levels in response to sympathetic nerve stimulation was studied in rats. 2 Rats which had been chronically treated with morphine in their drinking fluid for 21 days were shown to be morphine-tolerant, as revealed by the tail-immersion test for analgesia. 3 It was found that animals given either acute or chronic morphine treatment had similar basal concentrations of arterial catecholamines to their controls. 4 Sympathetic nerve stimulation produced significant increases in arterial noradrenaline and adrenaline levels in both the control and morphine-treated animals. However, the degree of arterial noradrenaline elevation was significantly less in morphine-tolerant animals. 5 This phenomenon was not observed in acutely morphine-treated rats or at 2 weeks following opiate withdrawal in animals which had been treated previously with morphine for 3 weeks. 6 The findings suggest that chronic morphine treatment in rats not only leads to opiate tolerance but also reduces catecholamine release in response to sympathetic nerve stimulation.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1-
dc.relation.ispartofBritish Journal of Pharmacology-
dc.titleArterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1476-5381.1989.tb11899.x-
dc.identifier.pmid2743083-
dc.identifier.pmcidPMC1854453-
dc.identifier.hkuros139667-
dc.identifier.volume96-
dc.identifier.issue4-
dc.identifier.spage888-
dc.identifier.epage894-
dc.publisher.placeUnited Kingdom-

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