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Article: Prognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma

TitlePrognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma
Authors
Issue Date2015
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.diagnosticpathology.org
Citation
Diagnostic Pathology, 2015, v. 10 n. 1, p. Article no. 192 How to Cite?
AbstractBackground: Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C in esophageal squamous cell carcinoma (ESCC) remains unexplored. The purpose of present study is to illustrate the role of FAM3C in predicting outcomes of patients with ESCC. Methods: FAM3C expression was measured in ESCC tissues and the matched adjacent nontumorous tissues by quantitative real-time RT-PCR and Western blot analysis. The relationship between FAM3C expression and prognosis of ESCC patients was further evaluated by univariate and multivariate regression analyses. Univariate and multivariate analyses of the prognostic factors were performed using Cox proportional hazards model. Results: The FAM3C mRNA expression was remarkably upregulated in ESCC compared with their nontumor counterparts (P < 0.001). In addition, high expression of FAM3C was significantly associated with pT stage (P = 0.014) , pN stage (P = 0.026) and TNM stage (P = 0.003). Kaplan-Meier analysis showed that the 7-year overall survival rate in the group with high expression of FAM3C was poorer than that in low expression group (32.0 versus 70.9 %; P < 0.001). Univariate and multivariate analyses demonstrated that FAM3C was an independent risk factor for overall survival. Moreover, Stratified analysis revealed that FAM3C expression could differentiate the prognosis of patients in early clinical stage (TNM stage I-II). Conclusions:FAM3C expression was dramatically increased in ESCC and might serve as a valuable prognostic indicator for ESCC patients after surgery. © 2015 Zhu et al.
Persistent Identifierhttp://hdl.handle.net/10722/222478
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.775
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhu, YH-
dc.contributor.authorZhang, B-
dc.contributor.authorLi, M-
dc.contributor.authorHuang, P-
dc.contributor.authorSun, J-
dc.contributor.authorFu, J-
dc.contributor.authorGuan, X-
dc.date.accessioned2016-01-18T07:41:06Z-
dc.date.available2016-01-18T07:41:06Z-
dc.date.issued2015-
dc.identifier.citationDiagnostic Pathology, 2015, v. 10 n. 1, p. Article no. 192-
dc.identifier.issn1746-1596-
dc.identifier.urihttp://hdl.handle.net/10722/222478-
dc.description.abstractBackground: Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C in esophageal squamous cell carcinoma (ESCC) remains unexplored. The purpose of present study is to illustrate the role of FAM3C in predicting outcomes of patients with ESCC. Methods: FAM3C expression was measured in ESCC tissues and the matched adjacent nontumorous tissues by quantitative real-time RT-PCR and Western blot analysis. The relationship between FAM3C expression and prognosis of ESCC patients was further evaluated by univariate and multivariate regression analyses. Univariate and multivariate analyses of the prognostic factors were performed using Cox proportional hazards model. Results: The FAM3C mRNA expression was remarkably upregulated in ESCC compared with their nontumor counterparts (P < 0.001). In addition, high expression of FAM3C was significantly associated with pT stage (P = 0.014) , pN stage (P = 0.026) and TNM stage (P = 0.003). Kaplan-Meier analysis showed that the 7-year overall survival rate in the group with high expression of FAM3C was poorer than that in low expression group (32.0 versus 70.9 %; P < 0.001). Univariate and multivariate analyses demonstrated that FAM3C was an independent risk factor for overall survival. Moreover, Stratified analysis revealed that FAM3C expression could differentiate the prognosis of patients in early clinical stage (TNM stage I-II). Conclusions:FAM3C expression was dramatically increased in ESCC and might serve as a valuable prognostic indicator for ESCC patients after surgery. © 2015 Zhu et al.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.diagnosticpathology.org-
dc.relation.ispartofDiagnostic Pathology-
dc.rightsDiagnostic Pathology. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePrognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma-
dc.typeArticle-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityGuan, X=rp00454-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13000-015-0424-8-
dc.identifier.pmid26498278-
dc.identifier.pmcidPMC4619363-
dc.identifier.scopuseid_2-s2.0-84945130206-
dc.identifier.hkuros256786-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spageArticle no. 192-
dc.identifier.epageArticle no. 192-
dc.identifier.isiWOS:000363372400001-
dc.publisher.placeUnited Kingdom-

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