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- Publisher Website: 10.1186/s13000-015-0424-8
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Article: Prognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma
Title | Prognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma |
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Authors | |
Keywords | EMT ESCC FAM3C Prognosis |
Issue Date | 2015 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.diagnosticpathology.org |
Citation | Diagnostic Pathology, 2015, v. 10 n. 1, p. Article no. 192 How to Cite? |
Abstract | Background: Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C in esophageal squamous cell carcinoma (ESCC) remains unexplored. The purpose of present study is to illustrate the role of FAM3C in predicting outcomes of patients with ESCC. Methods: FAM3C expression was measured in ESCC tissues and the matched adjacent nontumorous tissues by quantitative real-time RT-PCR and Western blot analysis. The relationship between FAM3C expression and prognosis of ESCC patients was further evaluated by univariate and multivariate regression analyses. Univariate and multivariate analyses of the prognostic factors were performed using Cox proportional hazards model. Results: The FAM3C mRNA expression was remarkably upregulated in ESCC compared with their nontumor counterparts (P < 0.001). In addition, high expression of FAM3C was significantly associated with pT stage (P = 0.014) , pN stage (P = 0.026) and TNM stage (P = 0.003). Kaplan-Meier analysis showed that the 7-year overall survival rate in the group with high expression of FAM3C was poorer than that in low expression group (32.0 versus 70.9 %; P < 0.001). Univariate and multivariate analyses demonstrated that FAM3C was an independent risk factor for overall survival. Moreover, Stratified analysis revealed that FAM3C expression could differentiate the prognosis of patients in early clinical stage (TNM stage I-II). Conclusions:FAM3C expression was dramatically increased in ESCC and might serve as a valuable prognostic indicator for ESCC patients after surgery. © 2015 Zhu et al. |
Persistent Identifier | http://hdl.handle.net/10722/222478 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.697 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhu, YH | - |
dc.contributor.author | Zhang, B | - |
dc.contributor.author | Li, M | - |
dc.contributor.author | Huang, P | - |
dc.contributor.author | Sun, J | - |
dc.contributor.author | Fu, J | - |
dc.contributor.author | Guan, X | - |
dc.date.accessioned | 2016-01-18T07:41:06Z | - |
dc.date.available | 2016-01-18T07:41:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Diagnostic Pathology, 2015, v. 10 n. 1, p. Article no. 192 | - |
dc.identifier.issn | 1746-1596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222478 | - |
dc.description.abstract | Background: Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C in esophageal squamous cell carcinoma (ESCC) remains unexplored. The purpose of present study is to illustrate the role of FAM3C in predicting outcomes of patients with ESCC. Methods: FAM3C expression was measured in ESCC tissues and the matched adjacent nontumorous tissues by quantitative real-time RT-PCR and Western blot analysis. The relationship between FAM3C expression and prognosis of ESCC patients was further evaluated by univariate and multivariate regression analyses. Univariate and multivariate analyses of the prognostic factors were performed using Cox proportional hazards model. Results: The FAM3C mRNA expression was remarkably upregulated in ESCC compared with their nontumor counterparts (P < 0.001). In addition, high expression of FAM3C was significantly associated with pT stage (P = 0.014) , pN stage (P = 0.026) and TNM stage (P = 0.003). Kaplan-Meier analysis showed that the 7-year overall survival rate in the group with high expression of FAM3C was poorer than that in low expression group (32.0 versus 70.9 %; P < 0.001). Univariate and multivariate analyses demonstrated that FAM3C was an independent risk factor for overall survival. Moreover, Stratified analysis revealed that FAM3C expression could differentiate the prognosis of patients in early clinical stage (TNM stage I-II). Conclusions:FAM3C expression was dramatically increased in ESCC and might serve as a valuable prognostic indicator for ESCC patients after surgery. © 2015 Zhu et al. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.diagnosticpathology.org | - |
dc.relation.ispartof | Diagnostic Pathology | - |
dc.rights | Diagnostic Pathology. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | EMT | - |
dc.subject | ESCC | - |
dc.subject | FAM3C | - |
dc.subject | Prognosis | - |
dc.title | Prognostic Significance of Fam3c in Esophageal Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Guan, X: xyguan@hkucc.hku.hk | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s13000-015-0424-8 | - |
dc.identifier.pmid | 26498278 | - |
dc.identifier.pmcid | PMC4619363 | - |
dc.identifier.scopus | eid_2-s2.0-84945130206 | - |
dc.identifier.hkuros | 256786 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | Article no. 192 | - |
dc.identifier.epage | Article no. 192 | - |
dc.identifier.isi | WOS:000363372400001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1746-1596 | - |