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Article: Biomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex

TitleBiomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex
Authors
KeywordsComplexation
Crystal growth
Drug dosage
Nanostructured materials
Porous materials
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
Citation
Materials Letters, 2006, v. 60 n. 29-30, p. 3533-3536 How to Cite?
AbstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6 mM, Ca/P = 1.67) was added into a PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC–HA, has a complicated porous structure that is expected to have high biocompatibility and that may be of use as materials for bone replacement and a carrier for controlled-release therapeutic agents.
Persistent Identifierhttp://hdl.handle.net/10722/222431
ISSN
2015 Impact Factor: 2.437
2015 SCImago Journal Rankings: 0.807

 

DC FieldValueLanguage
dc.contributor.authorLi, QL-
dc.contributor.authorChen, ZQ-
dc.contributor.authorDarvell, BW-
dc.contributor.authorZeng, Q-
dc.contributor.authorLi, G-
dc.contributor.authorOu, GM-
dc.contributor.authorWu, MY-
dc.date.accessioned2016-01-18T04:02:52Z-
dc.date.available2016-01-18T04:02:52Z-
dc.date.issued2006-
dc.identifier.citationMaterials Letters, 2006, v. 60 n. 29-30, p. 3533-3536-
dc.identifier.issn0167-577X-
dc.identifier.urihttp://hdl.handle.net/10722/222431-
dc.description.abstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6 mM, Ca/P = 1.67) was added into a PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC–HA, has a complicated porous structure that is expected to have high biocompatibility and that may be of use as materials for bone replacement and a carrier for controlled-release therapeutic agents.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet-
dc.relation.ispartofMaterials Letters-
dc.rights© <2006>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectComplexation-
dc.subjectCrystal growth-
dc.subjectDrug dosage-
dc.subjectNanostructured materials-
dc.subjectPorous materials-
dc.titleBiomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex-
dc.typeArticle-
dc.identifier.emailDarvell, BW: hrdubwd@hkucc.hku.hk-
dc.identifier.authorityDarvell, BW=rp00007-
dc.identifier.doi10.1016/j.matlet.2006.03.046-
dc.identifier.scopuseid_2-s2.0-33750421880-
dc.identifier.hkuros128898-
dc.identifier.volume60-
dc.identifier.issue29-30-
dc.identifier.spage3533-
dc.identifier.epage3536-
dc.publisher.placeNetherlands-

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