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Article: Bile immunoglobulin of the duck (Anas platyrhynchos). II. Antibody response in influenza A virus infections

TitleBile immunoglobulin of the duck (Anas platyrhynchos). II. Antibody response in influenza A virus infections
Authors
Issue Date1987
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM
Citation
Immunology, 1987, v. 62 n. 3, p. 499-504 How to Cite?
AbstractThe capacity of the IgM-like bile immunoglobulin (IgX) of the duck (Anas platyrhynchos) to express antibody activity to H3N2 influenza A viruses, and the dependence of this activity on the co-existence of serum IgM antibodies were investigated. Ducklings infected orally and intranasally at 15-29 days of age with viruses isolated from different host species were examined for haemagglutination-inhibiting (HI) antibodies in biles and sera 16-29 days after infection (p.i.). All biles had antibodies associated with IgX; all sera had antibodies associated only with the 7.8S IgG. Following oral infection of birds 42-days-old with influenza A/duck/HK/7/75 virus, serum HI antibodies were an initial IgM response occurring from 5-12 days p.i., followed by the appearance of 7.8S IgG antibodies. Virus-neutralizing (VN) antibodies in serum were also biphasic; isotype classification was not attempted. Bile IgX developed HI and VN activity. HI antibodies reached peak titres 12 days p.i. and fell to low levels by 24 days p.i. VN antibodies also reached peak titres 12 days p.i., but thereafter persisted at quite high levels throughout the experiment. Development of high titres of antibody in bile coincided with the termination of virus excretion in faeces. These experiments confirm that bile IgX of the duck can function as antibody in response to influenza A viruses, and that its activity appears to be independent of serum IgM. Its possible relevance in determining survival of virus in the intestine is discussed.
DescriptionPubFree
Persistent Identifierhttp://hdl.handle.net/10722/222418
ISSN
2015 Impact Factor: 4.078
2015 SCImago Journal Rankings: 2.038
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHiggins, DA-
dc.contributor.authorShortridge, KF-
dc.contributor.authorNg, PL-
dc.date.accessioned2016-01-15T02:13:04Z-
dc.date.available2016-01-15T02:13:04Z-
dc.date.issued1987-
dc.identifier.citationImmunology, 1987, v. 62 n. 3, p. 499-504-
dc.identifier.issn0019-2805-
dc.identifier.urihttp://hdl.handle.net/10722/222418-
dc.descriptionPubFree-
dc.description.abstractThe capacity of the IgM-like bile immunoglobulin (IgX) of the duck (Anas platyrhynchos) to express antibody activity to H3N2 influenza A viruses, and the dependence of this activity on the co-existence of serum IgM antibodies were investigated. Ducklings infected orally and intranasally at 15-29 days of age with viruses isolated from different host species were examined for haemagglutination-inhibiting (HI) antibodies in biles and sera 16-29 days after infection (p.i.). All biles had antibodies associated with IgX; all sera had antibodies associated only with the 7.8S IgG. Following oral infection of birds 42-days-old with influenza A/duck/HK/7/75 virus, serum HI antibodies were an initial IgM response occurring from 5-12 days p.i., followed by the appearance of 7.8S IgG antibodies. Virus-neutralizing (VN) antibodies in serum were also biphasic; isotype classification was not attempted. Bile IgX developed HI and VN activity. HI antibodies reached peak titres 12 days p.i. and fell to low levels by 24 days p.i. VN antibodies also reached peak titres 12 days p.i., but thereafter persisted at quite high levels throughout the experiment. Development of high titres of antibody in bile coincided with the termination of virus excretion in faeces. These experiments confirm that bile IgX of the duck can function as antibody in response to influenza A viruses, and that its activity appears to be independent of serum IgM. Its possible relevance in determining survival of virus in the intestine is discussed.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMM-
dc.relation.ispartofImmunology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAntibodies, Viral - analysis-
dc.subject.meshBile - immunology-
dc.subject.meshImmunoglobulins - analysis-
dc.subject.meshInfluenza A virus - immunology-
dc.subject.meshInfluenza in Birds - immunology-
dc.titleBile immunoglobulin of the duck (Anas platyrhynchos). II. Antibody response in influenza A virus infections-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid3451744-
dc.identifier.pmcidPMC1454141-
dc.identifier.volume62-
dc.identifier.issue3-
dc.identifier.spage499-
dc.identifier.epage504-
dc.publisher.placeUnited Kingdom-

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