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Article: β-Adrenoceptor activates endothelium-dependent release of nitric oxide in rat aorta

Titleβ-Adrenoceptor activates endothelium-dependent release of nitric oxide in rat aorta
Authors
Issue Date1995
PublisherScience Press (科學出版社).
Citation
Acta Pharmacologica Sinica, 1995, v. 16 n. 5, p. 385-390 How to Cite?
中國藥理學報 (英文版), 1995, v. 16 n. 5, p. 385-390 How to Cite?
AbstractAIM: To examine the possible role of agents elevating cAMP to release NO from aortic endothelial cells. METHODS: NG-nitro-L-arg inine methylester (L-NAME), an inhibitor of NO synthase, partially inhibited endothelium-dependent relaxation evoked in phenylephrine-precontracted rings by isoproterenol and abolished relaxation mediated by forskolin 0.2 mumol L-1. RESULTS: In rings without endothelium, isoproterenol and forskolin were less effective relaxants and L-NAME had no effect on the responses. In methylene blue-treated rings isoproterenol- and forskolin-induced relaxation were prevented in both endothelium-intact and -denuded rings, but the inhibitory effect of methylene blue were significantly more in rings with endothelium than in those without. On the other hand, relaxation induced by sodium nitroprusside was not inhibited by L-NAME, but was inhibited by methylene blue in both the endothelium-intact and -denuded rings. The concentration-relaxation curves to sodium nitroprusside after methylene blue were identical for rings with and without endothelium. CONCLUSION: beta-Adrenoceptors or any agent which raises cAMP elevate NO release from endothelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/222413
ISSN
2000 Impact Factor: 0.485

 

DC FieldValueLanguage
dc.contributor.authorZheng, XF-
dc.contributor.authorKwan, CY-
dc.contributor.authorDaniel, EE-
dc.date.accessioned2016-01-14T06:25:42Z-
dc.date.available2016-01-14T06:25:42Z-
dc.date.issued1995-
dc.identifier.citationActa Pharmacologica Sinica, 1995, v. 16 n. 5, p. 385-390-
dc.identifier.citation中國藥理學報 (英文版), 1995, v. 16 n. 5, p. 385-390-
dc.identifier.issn0253-9756-
dc.identifier.urihttp://hdl.handle.net/10722/222413-
dc.description.abstractAIM: To examine the possible role of agents elevating cAMP to release NO from aortic endothelial cells. METHODS: NG-nitro-L-arg inine methylester (L-NAME), an inhibitor of NO synthase, partially inhibited endothelium-dependent relaxation evoked in phenylephrine-precontracted rings by isoproterenol and abolished relaxation mediated by forskolin 0.2 mumol L-1. RESULTS: In rings without endothelium, isoproterenol and forskolin were less effective relaxants and L-NAME had no effect on the responses. In methylene blue-treated rings isoproterenol- and forskolin-induced relaxation were prevented in both endothelium-intact and -denuded rings, but the inhibitory effect of methylene blue were significantly more in rings with endothelium than in those without. On the other hand, relaxation induced by sodium nitroprusside was not inhibited by L-NAME, but was inhibited by methylene blue in both the endothelium-intact and -denuded rings. The concentration-relaxation curves to sodium nitroprusside after methylene blue were identical for rings with and without endothelium. CONCLUSION: beta-Adrenoceptors or any agent which raises cAMP elevate NO release from endothelial cells.-
dc.languageeng-
dc.publisherScience Press (科學出版社).-
dc.relation.ispartofActa Pharmacologica Sinica-
dc.relation.ispartof中國藥理學報 (英文版)-
dc.subject.meshAdrenergic beta-Agonists - pharmacology-
dc.subject.meshArginine - analogs & derivatives - pharmacology-
dc.subject.meshEndothelium, Vascular - physiology-
dc.subject.meshMuscle Relaxation - drug effects-
dc.subject.meshMuscle, Smooth, Vascular - drug effects-
dc.titleβ-Adrenoceptor activates endothelium-dependent release of nitric oxide in rat aorta-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid8701749-
dc.identifier.hkuros11243-
dc.identifier.volume16-
dc.identifier.issue5-
dc.identifier.spage385-
dc.identifier.epage390-
dc.publisher.placeBeijing (北京)-

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