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Article: Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression

TitleReduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression
Authors
Issue Date2015
Citation
Neurology, 2015, v. 84, n. 5, p. 516-522 How to Cite?
Abstract© 2015 American Academy of Neurology. Objective: To investigate dopamine transmission in patients with comorbid REM sleep behavior disorder (RBD) and major depressive disorder (MDD). Methods: This is a case-control study including 11 medicated patients with comorbid RBD and MDD (mean age 47.5 6 8.2), 8 medicated patients with MDD only (mean age 47.9 6 8.4), and 10 healthy participants (mean age 46.5 6 10.6 years). They underwent clinical assessment, video-polysomnography, olfactory tests, and neuroimaging studies (18F-DOPA, 11C-raclopride, and 18F-FDG PET neuroimaging). Results: Compared with the 2 control groups, patients with comorbid RBD and MDD had significantly lower 18F-DOPA uptake at 60 minutes in the putamen and caudate after controlling for age and sex effect (p < 0.05). There were no significant differences for the 11C-raclopride and 18F-FDG-PET. The 18F-DOPA uptake in putamens had significant inverse correlation with severity of RBD symptoms (p <0.01) and REM-related tonic muscle activity (p <0.01). The comorbid RBD and MDD group had more impairment in olfactory function. Conclusion: Patients with comorbid RBD and MDD had presynaptic dopamine dysfunction and impaired olfactory function. There is a distinct possibility that the development of RBD symptoms among patients with MDD may represent an early phase of a-synucleinopathy neurodegeneration instead of a merely antidepressant-induced condition.
Persistent Identifierhttp://hdl.handle.net/10722/222178
ISSN
2015 Impact Factor: 8.166
2015 SCImago Journal Rankings: 3.691

 

DC FieldValueLanguage
dc.contributor.authorWing, Yun Kwok-
dc.contributor.authorLam, Siu Ping-
dc.contributor.authorZhang, Jihui-
dc.contributor.authorLeung, Eric-
dc.contributor.authorHo, Chi Lai-
dc.contributor.authorChen, Sirong-
dc.contributor.authorCheung, Man Ki-
dc.contributor.authorLi, Shirley Xin-
dc.contributor.authorChan, Joey Wing Yan-
dc.contributor.authorMok, Vincent-
dc.contributor.authorTsoh, Joshua-
dc.contributor.authorChan, Anne-
dc.contributor.authorHo, Crover Kwok Wah-
dc.date.accessioned2015-12-21T06:49:12Z-
dc.date.available2015-12-21T06:49:12Z-
dc.date.issued2015-
dc.identifier.citationNeurology, 2015, v. 84, n. 5, p. 516-522-
dc.identifier.issn0028-3878-
dc.identifier.urihttp://hdl.handle.net/10722/222178-
dc.description.abstract© 2015 American Academy of Neurology. Objective: To investigate dopamine transmission in patients with comorbid REM sleep behavior disorder (RBD) and major depressive disorder (MDD). Methods: This is a case-control study including 11 medicated patients with comorbid RBD and MDD (mean age 47.5 6 8.2), 8 medicated patients with MDD only (mean age 47.9 6 8.4), and 10 healthy participants (mean age 46.5 6 10.6 years). They underwent clinical assessment, video-polysomnography, olfactory tests, and neuroimaging studies (<sup>18</sup>F-DOPA, 11C-raclopride, and <sup>18</sup>F-FDG PET neuroimaging). Results: Compared with the 2 control groups, patients with comorbid RBD and MDD had significantly lower <sup>18</sup>F-DOPA uptake at 60 minutes in the putamen and caudate after controlling for age and sex effect (p < 0.05). There were no significant differences for the 11C-raclopride and <sup>18</sup>F-FDG-PET. The <sup>18</sup>F-DOPA uptake in putamens had significant inverse correlation with severity of RBD symptoms (p <0.01) and REM-related tonic muscle activity (p <0.01). The comorbid RBD and MDD group had more impairment in olfactory function. Conclusion: Patients with comorbid RBD and MDD had presynaptic dopamine dysfunction and impaired olfactory function. There is a distinct possibility that the development of RBD symptoms among patients with MDD may represent an early phase of a-synucleinopathy neurodegeneration instead of a merely antidepressant-induced condition.-
dc.languageeng-
dc.relation.ispartofNeurology-
dc.titleReduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1212/WNL.0000000000001215-
dc.identifier.pmid25568298-
dc.identifier.scopuseid_2-s2.0-84925969884-
dc.identifier.volume84-
dc.identifier.issue5-
dc.identifier.spage516-
dc.identifier.epage522-
dc.identifier.eissn1526-632X-

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