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Article: IMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF

TitleIMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF
Authors
KeywordsMOWSE
PMF
Molecular weight search
Peptide mass fingerprinting
Issue Date2012
Citation
International Journal of Data Mining and Bioinformatics, 2012, v. 6, n. 1, p. 104-113 How to Cite?
AbstractWe demonstrated an unexplored issue in Peptide Mass Fingerprinting, 'cleavage site clusters', and formulated iMOWSE to distinguish true positives from false positives. We showed how the cleavage site clusters skew peptide database composition. Concerning the information content of an in silico digestion of a protein, both the number of matches of long peptides and the number of such peptides an entry can generate are taken into account. The resultant iMOWSE allows tolerance of deviation of query mass values from theoretical mass values and fewer matches are needed to identify true positives. Copyright © 2012 Inderscience Enterprises Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/222177
ISSN
2015 Impact Factor: 0.528
2015 SCImago Journal Rankings: 0.289

 

DC FieldValueLanguage
dc.contributor.authorLeung, Ross K K-
dc.contributor.authorTsui, Stephen K W-
dc.date.accessioned2015-12-21T06:49:11Z-
dc.date.available2015-12-21T06:49:11Z-
dc.date.issued2012-
dc.identifier.citationInternational Journal of Data Mining and Bioinformatics, 2012, v. 6, n. 1, p. 104-113-
dc.identifier.issn1748-5673-
dc.identifier.urihttp://hdl.handle.net/10722/222177-
dc.description.abstractWe demonstrated an unexplored issue in Peptide Mass Fingerprinting, 'cleavage site clusters', and formulated iMOWSE to distinguish true positives from false positives. We showed how the cleavage site clusters skew peptide database composition. Concerning the information content of an in silico digestion of a protein, both the number of matches of long peptides and the number of such peptides an entry can generate are taken into account. The resultant iMOWSE allows tolerance of deviation of query mass values from theoretical mass values and fewer matches are needed to identify true positives. Copyright © 2012 Inderscience Enterprises Ltd.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Data Mining and Bioinformatics-
dc.subjectMOWSE-
dc.subjectPMF-
dc.subjectMolecular weight search-
dc.subjectPeptide mass fingerprinting-
dc.titleIMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1504/IJDMB.2012.045543-
dc.identifier.pmid22479821-
dc.identifier.scopuseid_2-s2.0-84857757576-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spage104-
dc.identifier.epage113-
dc.identifier.eissn1748-5681-

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