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Conference Paper: Evolutionary sequence divergence predicts protein sub-cellular localization signals

TitleEvolutionary sequence divergence predicts protein sub-cellular localization signals
Authors
Issue Date2011
Citation
The 5th IEEE International Conference on Systems Biology (ISB 2011), Zhuhai, China, 2-4 September 2011. In Conference Proceedings, 2011, p. 307-312 How to Cite?
AbstractProtein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet been employed, despite its extensive use for tasks such as the prediction of transcription factor binding sites. Here, we flip the problem around, and present a proof of concept for the idea that the lack of sequence conservation can be a useful feature for localization prediction. © 2011 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/222175
ISBN

 

DC FieldValueLanguage
dc.contributor.authorFukasawa, Yoshinori-
dc.contributor.authorLeung, Ross K K-
dc.contributor.authorTsui, Stephen K W-
dc.contributor.authorHorton, Paul-
dc.date.accessioned2015-12-21T06:49:11Z-
dc.date.available2015-12-21T06:49:11Z-
dc.date.issued2011-
dc.identifier.citationThe 5th IEEE International Conference on Systems Biology (ISB 2011), Zhuhai, China, 2-4 September 2011. In Conference Proceedings, 2011, p. 307-312-
dc.identifier.isbn978-145771666-9-
dc.identifier.urihttp://hdl.handle.net/10722/222175-
dc.description.abstractProtein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others. Surprisingly, sequence conservation of sorting motifs has not yet been employed, despite its extensive use for tasks such as the prediction of transcription factor binding sites. Here, we flip the problem around, and present a proof of concept for the idea that the lack of sequence conservation can be a useful feature for localization prediction. © 2011 IEEE.-
dc.languageeng-
dc.relation.ispartofIEEE International Conference on Systems Biology, ISB 2011-
dc.titleEvolutionary sequence divergence predicts protein sub-cellular localization signals-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1109/ISB.2011.6033170-
dc.identifier.scopuseid_2-s2.0-80054860314-
dc.identifier.spage307-
dc.identifier.epage312-
dc.customcontrol.immutablesml 160506 - amended-

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